Sullivan et al., J Immunol 2007
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TICAM1 activates NF-kappaB through two different pathways involving its interactions with TNFR associated factor 6 and receptor interacting protein 1 ... In this study, we describe the role of zebrafish ( Danio rerio ) TICAM1 in activating NF-kappaB and zebrafish type I IFN
Funami et al., J Immunol 2007
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The receptor interacting protein 1 (RIP1), a crucial signaling molecule for TICAM-1 mediated NF-kappaB activation, accumulated in the TICAM-1 speckles
Funami et al., J Biol Chem 2008
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In this study, we show that homo-oligomerization of TICAM-1 is critical for TICAM-1 mediated activation of NF-kappaB and IRF-3