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CASP10 — TNFRSF10A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Leverkus et al., J Invest Dermatol 2003
(Dermatitis) :
By employing receptor-specific blocking antibodies we demonstrate that
TRAIL receptor 1 plays the primary role in mediating
caspase activation and apoptosis in HaCaT cells
Engels et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Interestingly, neutralization of TRAIL receptor 2 (TRAIL-R2), but not
TRAIL-R1 , impaired apoptosis in a
caspase-10 dependent manner, indicating that caspase-10 enhances TRAIL-R2 induced cell death
Mazumdar et al., PloS one 2012
:
Gelsolin modulation of cell death using this fragment involved upregulation of
TRAIL-R1 and TRAIL-R2, and
involved caspase 3 activation by extrinsic pathway