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IFNG — IVL

Text-mined interactions from Literome

Takahashi et al., Biochem J 1999 : Interferon-gamma dependent stimulation of human involucrin gene expression : STAT1 ( signal transduction and activators of transcription 1 ) protein activates involucrin promoter activity ... Using cultured normal human keratinocytes ( NHK cells ) and simian virus 40-transformed human keratinocytes ( SVHK cells ), we investigated the effects of IFN-gamma on involucrin gene expression ... Deletion analyses of the p2463Luc vector revealed that the G1 region is critical for the IFN-gamma dependent up-regulation of the involucrin gene ... In contrast, transfection of a STAT1 dominant negative expression vector suppressed the IFN-gamma dependent up-regulation of involucrin promoter activity ... These results indicate that IFN-gamma stimulates expression of the human involucrin gene via the G1 ( -883 to -874 ) region of the involucrin gene promoter
Hirai et al., Exp Eye Res 2006 (Sjogren's Syndrome) : IFN-gamma stimulation significantly up-regulated TGase1 and unexpectedly repressed involucrin gene expression