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IFNG — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → IFNG (increases)
  Evidence: Treatment of human aortic smooth muscle cells with IFN gamma for 15 and 35 minutes activated the STAT3 activity together with its phosphorylation at Tyr 705.
• NCI Pathway Database IL12 signaling mediated by STAT4: STAT3 (dimer ) complex (STAT3) → IFN-gamma (IFNG) (transcription, activates) Szabo et al., Science 2002, Kusaba et al., J Biol Chem 2005
  Evidence: mutant phenotype, physical interaction, other species

Text-mined interactions from Literome

Caldenhoven et al., J Leukoc Biol 1999 : Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils ... We demonstrate that, in addition to STAT1alpha, STAT3 is also activated by IFN-gamma in human neutrophils ... The cell type-specific activation of STAT3 by IFN-gamma was also observed in neutrophils that are differentiated in vitro from human CD34+ hematopoietic stem cells
Cassatella et al., Blood 1999 : Whereas IFNgamma and granulocyte colony stimulating factor ( G-CSF ) are efficient inducers of STAT1 and STAT3 tyrosine phosphorylation in polymorphonuclear neutrophils ( PMN ), IL-10 fails to trigger STAT1 and STAT3 tyrosine and serine phosphorylation, therefore explaining its inability to induce the FcgammaRI expression in these cells
Park et al., Mol Endocrinol 2000 : TSH and IFN-gamma had different effects on STAT1 and STAT3 phosphorylation
Iwamoto et al., Oncogene 2000 (Acute-Phase Reaction) : In contrast, JAB could downregulate phosphorylation of STAT1 and STAT3 induced by interferon gamma (IFNgamma) and interleukin-6 (IL-6) plus soluble IL6 receptor ( sIL-6R ), respectively
Costa-Pereira et al., Proc Natl Acad Sci U S A 2002 : Normal cells exposed to IL-6 thus require a STAT3 dependent function(s) to down-regulate STAT1 activity and prevent an IFN-gamma-like response
Federici et al., J Immunol 2002 (Dermatitis, Allergic Contact...) : SOCS1 and SOCS3 overexpression in keratinocyte stable clones inhibited IFN-gamma induced phosphorylation of IFN-gammaR ( alpha ) and activation of STAT1 and STAT3
Orlovsky et al., Oncogene 2002 (Colonic Neoplasms) : Moreover, IFN-gamma induced the association of Fer and Stat3 and the newly formed complex was most stable at the down-regulated states of the two proteins
Jenab et al., Neuro Endocrinol Lett 2002 (Glioma) : We show that interleukin 6, leukemia inhibitory factor and interferon gamma treatment induce the nuclear STAT3 and STAT1 proteins to bind to the sis inducible element of c-fos in both C6 glioma cells and primary cortical astrocytes
Sehgal et al., Arch Biochem Biophys 2003 (Carcinoma, Hepatocellular...) : The ubiquitous protein tyrosine phosphatase (PTP) called `` T-cell protein tyrosine phosphatase '' has been reported to mediate Tyr-dephosphorylation of both interferon-gamma (IFN-gamma) induced PY-STAT1 and interkleukin-6 (IL-6) induced PY-STAT3 in some cell lines
Wang et al., J Clin Invest 2003 (Central Nervous System Neoplasms...) : An immune response also induced in the brain of the GIFN/STAT2-/- mice was associated with IFN-gamma gene expression by CD3+ T cells and the activation of the STAT1, STAT3 , STAT4, and STAT5 molecules
Kaur et al., J Neurochem 2003 (Neuroblastoma) : Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines ... CNTF or interleukin-6 induced an IFN-gamma STAT3 response in a variety of cells including SH-SY5Y human neuroblastoma, HMN-1 murine motor neuron hybrid cells, rat sympathetic neurons and human hepatoma HepG2 cells ... Further, H-35 hepatoma cells expressing gp130 receptor chimeras lacking either the SHP-2 docking site or the Box 3 STAT binding sites failed to enhance the IFN-gamma STAT3 response
Gatto et al., J Biol Chem 2004 : Even though IFNgamma triggered tyrosine phosphorylation of both STAT1 and STAT3 in macrophages and J774 cells, only STAT1 was appropriately activated and thus found to specifically bind to the SOCS-3/SBE oligonucleotide probe
Qing et al., J Biol Chem 2004 : Alternative activation of STAT1 and STAT3 in response to interferon-gamma ... STAT3 can also be activated weakly by IFNgamma , but the mechanism of activation and function of STAT3 as a part of the interferon response are not known ... In response to IFNgamma , SRC-family kinases are required to activate STAT3 ( but not STAT1 ) through tyrosine phosphorylation, whereas the receptor bound kinases JAK1 and JAK2 are required to activate both STATs
Ji et al., Glia 2004 (Encephalitis) : Since interferon-gamma (IFN-gamma) induced GAS-luciferase activity and tyrosine phosphorylation of STAT1 and STAT3 were lower in CIS transfected cells compared to control vector transfected cells, CIS could have anti-inflammatory activity
Park et al., J Immunol 2004 : Consistent with these observations, IFN-gamma induced phosphorylation of STAT1 and STAT3 was lower in C6 cells expressing RacN17 ( referred to as C6-RacN17 ) than in control cells ... Interestingly, Rac1 appeared to associate with IFN-gammaRalpha and augment the interaction of IFN-gammaR with either STAT1 or STAT3 in response to IFN-gamma
Ramana et al., Biochem Biophys Res Commun 2005 (Adenocarcinoma...) : The Src kinase inhibitor SU6656 suppressed IFN-gamma activation of Stat3 in both wild-type and Stat1-/- fibroblasts ... Knock down of Stat3 by short interfering RNA abrogated Stat3 activation and SOCS-3 induction by IFN-gamma in Stat1-/- fibroblasts ... In human fibrosarcoma cell line 2fTGH, IFN-gamma activated Stat1 but not Stat3
Akhurst et al., Hepatology 2005 (Acute Disease...) : We also show that IFNgamma induces STAT-3 phosphorylation in an oval cell line
Choi et al., Biochem Biophys Res Commun 2005 (Inflammation) : Both RA isoforms also reduced IFN-gamma induced activation of signal transducers and activators of transcription ( STAT ) 1, STAT3 , Janus kinase (JAK)1, and JAK2
Zavros et al., Oncogene 2005 (Adenocarcinoma...) : To determine whether STAT3 was regulated by IFNgamma , MKN45 cells were cocultured with IFNgamma or gastrin ... IFNgamma significantly stimulated phosphorylation of STAT3 in the MKN45 cell line, but not gastrin
Vasilenko et al., Tsitologiia 2004 : Here, we have compared STAT1 and STAT3 activation in response to IFNgamma , IFNalpha and epidermal growth factor (EGF) in A431 cells
Sakamoto et al., J Leukoc Biol 2005 : Stimulation of neutrophils with IFN-alpha or IFN-gamma resulted in tyrosine phosphorylation of STAT1 and STAT3 but not phosphorylation of STAT5, Akt, extracellular signal regulated kinase, and p38 mitogen activated protein kinase ... IFN-alpha- and IFN-gamma induced up-regulation of cIAP2 mRNA and protein, phosphorylation of STAT3 , and antiapoptotic effect were inhibited significantly by pretreatment of cells with AG490, a specific inhibitor of JAK2
Zhang et al., Exp Eye Res 2005 : Retinas from embryonic and neonatal stages showed that STAT3 but not STAT1 was activated in response to ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), fibroblast growth factor-1 (FGF1), fibroblast growth factor-2 (FGF2), epidermal growth factor (EGF), interferon-alpha ( IFN-alpha ) and interferon-gamma (IFN-gamma) in distinct patterns
Walters et al., Am J Pathol 2005 (Disease Models, Animal...) : However, Stat3 phosphorylation induced by PDGF, EGF, or IFN-gamma increased twofold in Stat1-/- fibroblasts compared to wild-type fibroblasts
Giannopoulou et al., American journal of physiology. Renal physiology 2006 (Fibrosis...) : Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action
Fang et al., Exp Cell Res 2006 (Cell Transformation, Neoplastic...) : Taken together, these results demonstrate that an intact mTOR pathway is critical for IFN-gamma induced suppression of pY-STAT3 and apoptosis
Wormald et al., J Biol Chem 2006 : In mouse livers and bone marrow derived macrophages, both interferon-gamma (IFNgamma) and interleukin-6 (IL-6) rapidly induced the tyrosine phosphorylation of signal transducer and activator of transcription-1 ( STAT1 ) and STAT3
Baumert et al., World J Gastroenterol 2006 : IFN-beta and IFN-gamma induced a strong increase of STAT1 and STAT3 tyrosine phosphorylation, while the effect of IFN-alpha was much weaker
Raymond et al., Virology 2006 : Expression of Tip in T cells increased activation of Stat1 and Stat3 , as well as activation of protein kinase RNA dependent ( PKR/p68 ) and interferon-gamma production
Kurdi et al., J Interferon Cytokine Res 2007 (Adenocarcinoma...) : IFN-gamma also activated Stat3
Kim et al., J Biol Chem 2008 (Glioma) : Culture of microglia on C6 glioma cell derived matrices also led to activation of STAT1, augmentation of IFN-gamma induced STAT-3 activation, and an increase in IFN-gamma activated site ( GAS ) -luciferase reporter activity
Bai et al., J Biol Chem 2008 : By selectively inhibiting STAT3 and not STAT1 signaling, we identified a number of candidate IFN-gamma-inducible , STAT3 dependent gene products by microarray analysis ... IFN-gamma induced STAT3 and STAT1 signaling in VSMCs demonstrated reciprocal inhibition ... STAT3 activation by IFN-gamma sensitized VSMCs to apoptosis triggered by both death receptor- and mitochondrial mediated pathways
Tanaka et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental) : Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads ... Therefore, SOCS1 is necessary for Th17 differentiation by suppressing antagonistic effect of IFN-gamma on both STAT3 and Smads ... Induction of SOCS3 can partly explain IFN-gamma mediated STAT3 suppression, while other mechanism ( s ) will be involved in IFN-gamma mediated Smad suppression
Norkina et al., Alcohol Clin Exp Res 2008 : Indeed, we observed significant down-regulation of IL-6-, IFNalpha- and IFNgamma induced STAT1 DNA binding as well as inhibition of IL-6- and IFNgamma induced STAT3 when alcohol was added to monocytes 3 hours prior to the cytokine stimulation
Leong et al., Breast Cancer Res Treat 2009 (Breast Neoplasms...) : We also demonstrate that Poly E blocked signal transducers and activators of transcription ( STAT ) signaling by suppressing interferon-gamma (IFN-gamma) induced gene transcription via IFN-gamma activating sequence ( GAS ) elements and downstream STAT3 activation by inhibiting STAT1 and STAT3 dimerization in MDA-MB231 cells
Goncharova et al., Mol Pharmacol 2009 (Lung Diseases...) : Re-expression of TSC2 or treatment with rapamycin inhibited IFN-gamma induced STAT3 phosphorylation and synergized with IFN-gamma in inhibiting TSC2-null and LAMD cell proliferation
Guo et al., Proc Natl Acad Sci U S A 2009 : Similarly, Th17 cells produce IL-17A in response to IL-1beta and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer
McGillicuddy et al., J Biol Chem 2009 (Insulin Resistance) : IFNgamma induced robust STAT1 phosphorylation and SOCS1 mRNA expression, with modest, transient STAT3 phosphorylation and SOCS3 induction
Scharl et al., Gastroenterology 2009 (Crohn Disease) : Moreover, IFN-gamma induced STAT1 and STAT3 phosphorylation in IEC is enhanced by PTPN2 knockdown
Qi et al., BMC bioinformatics 2013 : In particular, the unbalanced competition between STAT1 and STAT3 for IFNR and gp130 led to preferential activation of IFN-gamma and IL-6, while at the same time the formation of STAT1/3 heterodimers enhanced preferential signal transduction by sequestering a fraction of the activated STATs
Kordula et al., Biochem Biophys Res Commun 1995 (Carcinoma, Hepatocellular...) : The effect of IL-6 and IFN gamma on Stat3 mRNA expression was time- and dose dependent ... Moreover, we show that the rapid induction of Stat3 expression by IL-6 and IFN gamma was independent of ongoing protein synthesis, suggesting regulation by Stat3 and Stat1, respectively
King et al., Endocrinology 1995 : Dexamethasone does not inhibit induction of tyrosyl phosphorylation of ERK proteins by epidermal growth factor or phorbol myristate acetate, nor does it block induction of tyrosyl phosphorylation of Stat3/APRF by leukemia inhibitory factor or interleukin-6, or induction of JAK2 by leukemia inhibitory factor or interferon-gamma
Yu et al., J Immunol 1996 : Gel mobility shift and immunoprecipitation analyses revealed that in addition to activating STAT3 ( signal transducer and activator of transcription-3 ) and STAT5, IL-2 induced tyrosine and serine phosphorylation of STAT1 alpha, which formed IFN-gamma activated sequence binding complexes by itself and with STAT3
Jenab et al., Endocrinology 1997 : Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA binding activity to the sis-inducible element of c-fos in a genistein dependent pathway
Sato et al., Blood 1997 : We showed that, in KG-1a cells, IFN-gamma also induced phosphorylation of Stat1 and Stat3 , whereas p42 MAP kinase was phosphorylated regardless of the presence of IFN-gamma ... Using electrophoresis mobility shift assays, IFN-gamma enhanced Stat1-Stat1 homodimer and Stat1-Stat3 heterodimer formation, suggesting that, in addition to inhibitory signals mediated by IRF-1, IFN-gamma may activate proliferative signals by phosphorylation of Stat1 and Stat3 proteins
Balhoff et al., Biochem Biophys Res Commun 1998 : IFN-gamma is a potent activator of STAT 1 and a weaker activator of STAT 3 , whereas LIF and OSM are potent activators of STAT 3 and weaker activators of STAT 1
Wang et al., Ann Surg Oncol 1998 (Carcinoid Tumor...) : We have shown that both IFN-alpha and IFN-gamma can induce Stat protein binding ( particularly Stat3 and Stat5 ) to their cognate DNA consensus sites and increase Stat protein steady state levels in BON cells
Tsubota et al., Invest Ophthalmol Vis Sci 1999 (Sjogren's Syndrome) : IFN-gamma induced the nuclear translocation of NF-kappaB, but did not activate STAT1 or STAT3 in ChWK