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IFNG — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → IFNG (increases)
  Evidence: p53 and p21 protein levels were increased and pRb protein level was decreased in IFN-g-treated cells.
• OpenBEL Selventa BEL large corpus: TP53 → IFNG (increases)
  Evidence: We therefore measured p53 phosphorylation at serine 15 and ATM phosphorylation at serine 1981 in response to IFN-g. IFNg treatment induced the phosphorylations of p53 and ATM in a time-dependent manner (Fig. 5A).

Text-mined interactions from Literome

Bueter et al., Int J Oncol 2006 (Colorectal Neoplasms) : We observed that p53 induced both IFN-gamma and IL-10 secretion
Jiang et al., J Exp Clin Cancer Res 2007 (Carcinoma, Hepatocellular...) : Overexpression of IRF-1 augmented the combined interferon-gamma/adriamycin induced p53 accumulation
Sun et al., J Interferon Cytokine Res 2007 : Expression of IRF-1 was induced and expression of active caspase-3 was promoted by IFN-gamma treatment, but IFN-gamma did not affect the expression of IFNGR and p53
Oya et al., Int J Oncol 1997 : The p53 was induced by both 10 ( 2 ) and 10 ( 3 ) IU/ml IFN-gamma
Berry et al., Oncogene 1996 (Breast Neoplasms...) : However, IFN-gamma induced apoptosis in RB-defective lines does not require wild-type p53 suggesting that, upon IFN-gamma induction, deregulated E2F mediated apoptosis can also proceed via p53 independent pathways
Kano et al., J Biochem 1997 : Northern blot analysis demonstrated that IFN-gamma enhanced p53 mRNA expression as well as p21 ( WAF1/Cip1/Sdi1 ) mRNA expression, which is mediated by the increased expression of the p53 protein
Arany et al., Cancer Lett 1997 (Melanoma, Experimental) : On the other hand, IFN-gamma activates p53 expression without affecting the mda-6/WAF1 system