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GAB1 — MAPK3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK3
→
Complex of GAB1-PTPN11
(increases, GAB1/PTPN11 Activity)
Maroun et al., Mol Cell Biol 2000
Evidence: To elucidate the Gab1-dependent signals required for epithelial morphogenesis, we undertook a structure-function approach and demonstrate that association of Gab1 with the tyrosine phosphatase SHP-2 is required for sustained Erk activation and for epithelial morphogenesis downstream from the Met receptor.
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NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
Erk1-2 (MAPK3/MAPK1)
→
HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF)
(modification, collaborate)
Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
Evidence: mutant phenotype
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NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
Erk1-2 (MAPK3/MAPK1)
→
HGF(dimer)/MET(dimer)/GAB1/SHP2 complex (MET-GAB1-PTPN11-HGF)
(modification, collaborate)
Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
Evidence: mutant phenotype
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NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
Erk1-2-active (MAPK3/MAPK1)
→
HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF)
(modification, activates)
Yu et al., J Biol Chem 2001
Evidence: mutant phenotype
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cunnick et al., J Biol Chem 2001
:
Thus, physical association of activated SHP2 with
Gab1 is necessary and
sufficient to mediate the ERK
mitogen activated protein kinase activation
Cai et al., J Cell Biol 2002
(MAP Kinase Signaling System) :
Gab1 and SHP-2
promote Ras/MAPK regulation of epidermal growth and differentiation
Chen et al., J Biol Chem 2002
:
Incubation of cells with the specific EGFR inhibitor AG4178 blocked MbetaCD induced phosphorylation of EGFR, SHC, phospholipase C-gamma, and
Gab-1 as well as
MAPK activation
Lamothe et al., Mol Cell Biol 2004
:
We demonstrate that Gab1 is essential for FGF1 stimulation of both PI 3-kinase and the antiapoptotic protein kinase Akt, while FGF1 induced
mitogen activated protein kinase ( MAPK ) stimulation is not
affected by
Gab1 deficiency
Eulenfeld et al., J Cell Sci 2009
:
Instead, additional
MAPK dependent phosphorylation of Ser551 in
Gab1 is crucial for the recruitment of Gab1 to the plasma membrane