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CDKN1A — TRO

Text-mined interactions from Literome

Wakino et al., J Biol Chem 2001 : PPARgamma ligands troglitazone ( TRO , 10 microm ) and rosiglitazone ( RSG, 10 microm ) attenuated the induction of p21 ( Cip1 ) protein by platelet derived growth factor ( PDGF ) and insulin without affecting cognate mRNA levels in rat aortic smooth muscle cells ( RASMC ) ... TRO , RSG, and rottlerin inhibited PDGF induced expression of p21 ( Cip1 ), but they did not affect insulin induced expression of p21 ( Cip1 )
Kim et al., Cancer Lett 2002 (Colorectal Neoplasms) : The induction and nuclear localization of p21Cip/WAF1 by TRO were blocked by PD98059 pre-treatment, which suggested a role for the ERK pathway in p21Cip/WAF1 activation
Bae et al., Toxicol Lett 2003 (Liver Neoplasms) : Our results indicated that TRO increased the levels of p53, p27, and p21 , while it reduced the levels of cyclin D1 and phospho-Rb in a time dependent manner