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CNTF — TCF25
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Müller et al., Brain 2007
(Optic Nerve Injuries) :
We show here that LI or zymosan induce upregulation of
ciliary neurotrophic factor (CNTF) in retinal astrocytes and release CNTF independent of macrophages and
activate the
transcription factor signal transducers and activators of transcription 3 ( STAT3 ) in RGCs. Levels of CNTF expressed in retinal glia and STAT3 activation in RGC were correlated with the time course of RGCs switching to an active regenerative state
Wang et al., Neurosci Lett 1998
:
All-trans-retinoic acid induced as much as a 3-fold increase in CNTF receptor alpha subunit mRNA in a time and concentration dependent manner and resulted in an enhanced
CNTF induced tyrosine phosphorylation of the
transcription factor , STAT3