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JAK1 — TCF25
Text-mined interactions from Literome
Miller et al., J Immunol 1999
:
We demonstrate that HCMV
inhibits IFN-alpha stimulated MHC class I, IFN regulatory factor-1, MxA and 2',5-oligoadenylate synthetase gene expression,
transcription factor activation, and signaling in infected fibroblasts and endothelial cells by decreasing the expression of
Janus kinase 1 and p48, two essential components of the IFN-alpha signal transduction pathway
Madden et al., J Immunol 2002
:
Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates
Jak dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the
transcription factor , STAT6
Rani et al., J Interferon Cytokine Res 2007
:
TRAIL was not
induced by IFN-beta in mutant cell lines U2A, U3A, U4A, U5A, and U6A, which lack, respectively, IFN regulatory factor-9 (IRF-9), Stat1,
Jak1 , IFNAR-2.2, and Stat2, indicating
transcription factor IFN stimulated gene factor 3 ( ISGF3 ) was essential for the induction of this gene