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NGF — NPY
Text-mined interactions from Literome
Fiore et al., Behav Brain Res 1999
:
The results of our studies show : ( a ) that NGF is present in the brain of these birds and it is higher in the HVC than in the other neostriatal tissues ; ( b ) that exogenous administration of NGF or NGF-antibody had no discernible effect on singing behavior ; and ( c ) that
NGF enhances the
NPY immunoreactivity in neurons and fibers localized in HVC and other areas of the neostriatum and hippocampus whereas anti-NGF decreased NPY stained cells in the hippocampus
Medina-Ortiz et al., Brain Res Dev Brain Res 2000
:
Differential
regulation of
NPY mRNA expression in embryonic sympathetic and chromaffin cultures by
NGF
Li et al., Mol Endocrinol 2000
:
Molecular cloning, expression, and characterization of rat homolog of human AP-2alpha that stimulates
neuropeptide Y transcription activity in
response to
nerve growth factor ... We further demonstrated that rat AP-2a promotes efficient
NPY transcription activity in
response to
NGF
Barreto-Estrada et al., Brain Res Dev Brain Res 2003
:
Previously, we have shown that 11-day embryonic chick sympathetic cell cultures increased their
neuropeptide Y (NPY) protein and mRNA levels in the
presence of
NGF
Chen et al., Zhonghua Bing Li Xue Za Zhi 1992
(Neuroblastoma) :
Various gene expression of CGA and
NPY in neuroblastoma cell lines might be due to the presence of different stages of tumor cell differentiation and
NGF only
induced differentiation of those neuroblastoma cells ready to be differentiating to neurons afterwards
Tuttle et al., Brain Res 1992
:
Added
NGF also
affected the expression of
neuropeptide Y
Liu et al., Pharmazie 2010
:
It is not known whether or to what extent
NGF affects both galanin and
NPY expression in primary cultured SCG neurons
Balbi et al., Brain Res Mol Brain Res 1994
:
H7, an inhibitor of both PKC and PKA systems completely abolished the NGF induced increase in NPY mRNA, suggesting that PKC is necessary for
NGF induction of the
NPY gene ... Use of a reporter function, chloramphenicol acetyl transferase, controlled by 700 base pairs of the 5 ' flanking region of the NPY gene demonstrated that
NGF and phorbol ester
stimulated transcription of the
NPY gene ... Our results indicate that
NGF induces
NPY gene expression via activation of PKC system
Lapchak et al., Brain Res 1994
(Synaptic Transmission) :
Additionally, it appears that
NGF when administered in pharmacological doses is not
involved in the regulation of
NPY synthesis in the hippocampus or cortex despite the presence of an NGF-responsive element associated with the rat NPY gene
Minth-Worby et al., J Biol Chem 1994
:
Transcriptional
regulation of the human
neuropeptide Y gene by
nerve growth factor
Shimoda et al., Neurochem Int 1993
:
Though both
NPY and CAs in the cultured cells were positively
regulated by
NGF , the results of this study seemed to suggest a differential regulation for NPY and CAs in the chromaffin cell
Bracci-Laudiero et al., Neuroreport 1996
:
The stimulatory
effect of
NGF on
NPY production is not a common characteristic of all lymphocytes : only unstimulated T cells respond to NGF by synthesizing NPY
Ji et al., Regul Pept 1996
:
Using immunohistochemistry and in situ hybridization the in vivo
effects of acidic and basic fibroblast growth factor ( aFGF, bFGF ), and of
nerve growth factor (NGF) on the expression of galanin,
neuropeptide Y (NPY) and substance P in axotomized dorsal root ganglia ( DRGs ) were examined
Zigmond et al., Ann N Y Acad Sci 1997
:
Both the removal of
NGF and the exposure to LIF
inhibit NPY expression, while promoting the expression of VIP and galanin
Wernersson et al., J Neurochem 1998
:
Suppression of TPA induced NPY transcription was obtained by expression of a dominant negative Jun protein, selective protein kinase C inhibition, or introduction of a mutated TRE, whereas
NGF induced
NPY transcription was inhibited to a lesser degree