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CPOX — NOS2
Text-mined interactions from Literome
Chen et al., J Biol Chem 1999
:
The
cyclooxygenase-2 (COX-2) inhibitors, NS-398 and indomethacin,
attenuated LPS induced NO release,
iNOS expression, and NF-kappaB DNA-protein complex formation
Hashimoto et al., Hypertens Res 2003
:
On the other hand, the
COX inhibitors, indomethacin and NS-398,
had little effect on nitrite production or
iNOS expression
Ejima et al., Antioxid Redox Signal 2004
(Endotoxemia) :
The present article reviews our recent studies involving the role of
cyclooxygenase (COX)-2 in host responses to bacterial endotoxemia and its
role in the regulation of nitric oxide synthase
(NOS)2 and heme oxygenase (HO)-1
Won et al., Glia 2005
:
In contrast to LO, however, the
cyclooxygenase (COX) may not be
involved in the regulation of LPS mediated induction of
iNOS gene because COX inhibition by indomethacin ( general COX inhibitor ), SC560 ( COX-1 inhibitor ), and NS398 ( COX-2 inhibitor ) affected neither the LPS induced iNOS expression nor activation of NFkappaB
King et al., Neurosignals 2005
(Opioid-Related Disorders...) :
A non-inclusive list of examples of substances reported to block or reverse opioid antinociceptive tolerance include : substance P receptor ( NK-1 ) antagonists, calcitonin gene related peptide (CGRP) receptor antagonists,
nitric oxide ( NO ) synthase inhibitors, calcium channel blockers,
cyclooxygenase (COX) inhibitors , protein kinase C inhibitors, competitive and non-competitive antagonists of the NMDA ( N-methyl-D-aspartate ) receptor, AMPA ( alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid ) antagonists, anti-dynorphin antiserum, and cholecystokinin (CCK) receptor antagonists
Chang et al., Cell Signal 2006
(MAP Kinase Signaling System) :
LTA induced
iNOS expression and NO release were
inhibited by a non-selective
COX inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS-398 ), an adenylyl cyclase ( AC ) inhibitor ( dideoxyadenosine, DDA ), and a protein kinase A (PKA) inhibitor ( KT-5720 )
West et al., Crit Care Med 2008
:
We used nonselective and selective COX inhibitors to determine the
role of
COX on
inducible NOS (iNOS) expression in the gastric mucosa
Ye et al., Am J Physiol Heart Circ Physiol 2008
(Disease Models, Animal...) :
Activation of
COX2 is
dependent on
iNOS
Stanley et al., Vascul Pharmacol 2009
(Diabetes Complications...) :
Uterine arteries from term-pregnant, diabetic and control C57Bl6/J mice were assessed using acetylcholine ( ACh ; 10 ( -10 ) -10 ( -5 ) M ) in the
presence or absence of a
nitric oxide ( NO ) synthase inhibitor ( L-NNA ; 10 ( -5 ) M ), a
cyclooxygenase (COX) inhibitor ( indomethacin ; 10 ( -5 ) M ) or the two in combination
Arab et al., J Biol Chem 2010
(Hyperoxia...) :
This decrease in
COX expression is
prevented by the inhibition of
inducible nitric-oxide synthase (iNOS)
Obermajer et al., Transplantation research 2012
:
We observed that PGE2 induces endogenous
cyclooxygenase (COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and
inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ra,
nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
LaPointe et al., Hypertension 1998
:
Since NO has been shown to directly stimulate COX activity and the resulting prostanoids to modulate IL induction of iNOS, we questioned whether PLA2 and/or
COX products are
involved in IL regulation of
iNOS and NO production in NVM