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ARHGEF2 — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → ARHGEF2 (ARHGEF2) (modification, collaborate) Krendel et al., Nat Cell Biol 2002*, Ren et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• Reactome Reaction: ARHGEF2 → RAC1 (reaction) Harrington et al., J Neurosci 2002

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ARHGEF2 — RAC1 (direct interaction, pull down) Gao et al., J Biol Chem 2001*
• IRef Hprd Interaction: ARHGEF2 — RAC1 (in vivo) Gao et al., J Biol Chem 2001*, Ren et al., J Biol Chem 1998
• IRef Hprd Interaction: ARHGEF2 — RAC1 (in vitro) Gao et al., J Biol Chem 2001*, Ren et al., J Biol Chem 1998

Text-mined interactions from Literome

Guillemot et al., Mol Biol Cell 2008 : Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
Waheed et al., Mol Biol Cell 2013 : Central role of the exchange factor GEF-H1 in TNF-a induced sequential activation of Rac , ADAM17/TACE, and RhoA in tubular epithelial cells ... EGFR- and ERK dependent phosphorylation at the T678 site of GEF-H1 is a prerequisite for RhoA activation only, whereas both Rac and RhoA activation require GEF-H1 phosphorylation on S885