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PHKA2 — RAC1

Text-mined interactions from Literome

Hirotani et al., J Mol Cell Cardiol 2004 (Cardiomegaly) : Inhibition of Pyk2 activation also suppressed Rac1 activation and reactive oxygen species ( ROS ) production
Gakidis et al., J Cell Biol 2004 : beta2 induced activation of Cdc42, Rac1 , and RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2 , paxillin, and Akt is also significantly reduced
Hudson et al., Cell Microbiol 2005 : Under conditions of low concentrations of ECM, invasin was found to be the dominant adhesin, promoting high levels of phagocytosis coincident with robust and sustained activation of the protein tyrosine kinases Fak and Pyk2 , phosphorylation of the adaptor molecule Cas and activation of the small GTPase Rac1
Paulino et al., Mol Cancer Res 2010 (Brain Neoplasms...) : In addition, we show that TROY overexpression in glioma cells activates Rac1 signaling in a Pyk2 dependent manner to drive glioma cell invasion and migration ... Pyk2 coimmunoprecipitates with the TROY receptor, and depletion of Pyk2 expression by short hairpin RNA interference oligonucleotides inhibits TROY induced Rac1 activation and subsequent cellular migration
Gadepalli et al., Arterioscler Thromb Vasc Biol 2012 (Carotid Artery Injuries...) : In addition, adenovirus mediated expression of dominant negative Pyk2 inhibited thrombin induced Grb2 associated binder protein 1, p115 rho guanine nucleotide exchange factor, Rac1 , RhoA and Pak1 stimulation