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CXCL12 — PTGS2

Text-mined interactions from Literome

Põld et al., Cancer Res 2004 (Carcinoma, Non-Small-Cell Lung...) : Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer ... To elucidate the role of COX-2 in the in vitro and in vivo expression of two known NSCLC angiogenic peptides, CXC ligand ( CXCL ) 8 and CXCL5, we studied two COX-2 gene modified NSCLC cell lines, A549 and H157 ... COX-2 overexpression enhanced the in vitro expression of both CXCL8 and CXCL5
Brant et al., Toxicological sciences : an official journal of the Society of Toxicology 2009 : Consistent with our previous findings that Ni and MALP-2 stimulates the induction of CXCL8 via a COX-2 mediated pathway, CXCL1 , CXCL5, and VEGF release were also regulated by COX-2
Katoh et al., Am J Pathol 2010 (Neoplasms...) : Notably, COX-2 inhibition attenuated CXCL12/CXCR4 expression as well as expression of several other chemokines ... In addition, a COX-2 inhibitor suppressed stromal formation and reduced expression of CXCL12/CXCR4 and a fibroblast marker ( S100A4 ) in a micropore chamber model
Alvarez et al., J Neurochem 2010 : Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12 : role in neuronal toxicity ... CXCL12 induced COX-2 and secretion of PGE ( 2 ) in a dose dependent manner in human astrocytes
Obermajer et al., Cancer Res 2011 (Ovarian Neoplasms) : Similarly, COX2 inhibition also blocked CXCL12 production in the ovarian cancer environment and its ability to attract MDSCs. Together, our findings elucidate a central role for PGE ( 2 ) in MDSC accumulation triggered by the CXCL12-CXCR4 pathway, providing a powerful rationale to target PGE ( 2 ) signaling in ovarian cancer therapy