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HBEGF — PTGS2

Text-mined interactions from Literome

Seo et al., Biochem Biophys Res Commun 2010 (Cell Transformation, Neoplastic...) : In this study, we aimed to elucidate the role and underlying mechanism of the alpha subunit of Gq protein ( Galphaq ) in UVB induced HB-EGF secretion and COX-2 induction
Lee et al., Cell Signal 2011 : HB-EGF enhanced the expression of COX-2 , a response mediated by MEK5-ERK5 signaling, while the COX-2 inhibitor rofecoxib attenuated HB-EGF induced ANF mRNA expression, suggesting that COX-2 is also associated with HB-EGF induced cardiomyocyte hypertrophy ... It has been known that ERK5 activates the myocyte enhancer factor (MEF) 2 family of transcription factor, we next tested whether activation of MEF2A contributes to HB-EGF induced COX-2 expression ... Inhibition of MEF2A using siRNA attenuated HB-EGF induced COX-2 , ANF expression and cell size