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FOS — LPA
Text-mined interactions from Literome
Ediger et al., Eur Respir J 2003
(Cell Transformation, Neoplastic...) :
LPA and EGF both
activated activator protein (AP)-1 , cyclic adenosine monophosphate response element binding protein, nuclear factor of activated T-cells and the serum response element ; however, only AP-1 activation exhibited synergism
Fang et al., J Biol Chem 2004
(Ovarian Neoplasms) :
The optimal response of the IL-8 gene promoter to LPA relied on binding sites for NF-kappaB and
AP-1 , two transcription factors that were strongly
activated by
LPA in ovarian cancer cell lines
Oyesanya et al., Molecular cancer 2010
(Neoplasm Invasiveness) :
In ovarian cancer cells highly responsive to LPA, activation of AP-1 by LPA was suppressed by inhibition of EGFR, an effect that could be reversed by co-stimulation of another receptor tyrosine kinase c-Met with hepatocyte growth factor, indicating that
LPA mediated activation of
AP-1 requires activity of a RTK, not necessarily EGFR
Singla et al., Am J Physiol Gastrointest Liver Physiol 2012
:
Utilizing EMSA and mutational studies, our results showed that
LPA induced the DRA promoter activity in a
c-Fos dependent manner ...
LPA also
increased the protein expression of
c-Fos and c-Jun in Caco-2 cells
Chua et al., Biochim Biophys Acta 1998
:
Electrophoretic mobility shift assay revealed that
LPA stimulated the binding of
AP-1
Cook et al., Mol Cell Biol 1999
:
c-Fos , c-Jun, and JunB are induced rapidly in
response to
LPA stimulation, whereas Fra-1 and Fra-2 are induced after a significant lag ...
LPA stimulated expression of
c-Fos , Fra-1, Fra-2, c-Jun, and JunB is inhibited by the MEK1 inhibitor PD098059, indicating that the Raf-MEK-MAPK cascade is required for their expression