◀ Back to RAF1
CALM3 — RAF1
Text-mined interactions from Literome
Moretó et al., Cell Signal 2009
(MAP Kinase Signaling System) :
Though inhibition of
CaM , using the CaM antagonist W-13, significantly
increased Raf-1 activation by K-Ras-GTP, MAPK activation downstream K-Ras/Raf-1 was strongly reduced in COS-1 and several other cell lines ... In contrast, in other cell lines such as NIH3T3-wt8, W-13 mediated inhibition of
CaM increased
Raf-1 activity, but resulted in an increase in MAPK phosphorylation
Yoshiki et al., Mol Biol Cell 2010
(Calcium Signaling) :
Using a biosensor based on fluorescence resonance energy transfer, it was found that activation of
Raf1 at the plasma membrane
required not only Ras activation but also an increase in Ca ( 2+ ) concentration or inhibition of
calmodulin ... These observations indicated that the Shoc2 scaffold protein modulates Ras dependent
Raf1 activation in a Ca ( 2+ ) - and
calmodulin dependent manner