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FASLG — TNF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Khar et al., J Interferon Cytokine Res 1999
(Ascites) :
In the present study, we showed that
Fas-L expression on AK-5 cells is
regulated by interferon-gamma (IFN-gamma) and
tumor necrosis factor-alpha (TNF-alpha) , as injection of antibodies against IFN-gamma downregulated the expression of Fas-L by tumor cells as determined by immunostaining and Northern hybridizations
Naujokat et al., Biochem Biophys Res Commun 1999
(Adenocarcinoma) :
Tumor necrosis factor-alpha and interferon-gamma
induce expression of functional
Fas ligand on HT29 and MCF7 adenocarcinoma cells ... Here we show that
tumor necrosis factor-alpha (TNF-alpha) in addition to interferon-gamma (IFN-gamma)
induces cell surface expression of functional
FasL in human HT29 colon and MCF7 breast adenocarcinoma cells that constitutively lack cell surface expression of FasL ... These results demonstrate that
TNF-alpha and IFN-gamma
induce expression of functional
FasL in adenocarcinoma cells which thereby can kill T lymphocytes by the FasL/Fas pathway
Napoli et al., FASEB J 2000
(Arteriosclerosis) :
Blocking of
Fas ligand (FasL) reduced apoptosis by 50 % and simultaneous blocking of FasL and
TNF receptors by 70 %
Fortunato et al., Am J Obstet Gynecol 2001
(Infection) :
Neither lipopolysaccharide nor
tumor necrosis factor induced
Fas ligand expression in human fetal membranes
Pentikäinen et al., J Clin Endocrinol Metab 2001
:
Interestingly, expression of the
Fas ligand , a known inductor of testicular apoptosis, was
down-regulated by
TNFalpha ... Thus, in the seminiferous tubules, germ cell derived
TNFalpha may
regulate the level of the
Fas ligand and thereby control physiological germ cell apoptosis
Jo et al., Nephron 2002
:
Fas ligand protein expression did not
increase in the low-dose
TNF-alpha treated group, but it increased significantly in the high-dose TNF-alpha treated group ( p < 0.01 ), IL-1beta- and LPS treated groups ( p < 0.01, p = 0.01, p < 0.01, p = 0.02 )
Lu et al., Am J Physiol Cell Physiol 2002
:
Inhibition of NF-kappaB by a specific NF-kappaB inhibitor, caffeic acid phenylethyl ester, or by dominant expression of the NF-kappaB inhibitory subunit IkappaB caused an increase in
FasL induced apoptosis and a reduction in
TNF-alpha expression
Pinkoski et al., J Biol Chem 2002
:
TNFalpha induced activation of the
Fas-ligand promoter in IEC requires NF-kappaB as this was blocked by an I-kappaBalphaM super-repressor and by mutation of an NF-kappaB site in the Fas-ligand promoter ... These results define a novel pathway wherein
TNFalpha , produced by activated T cells in the intestine,
induce Fas-ligand expression in IEC
Kitaura et al., J Immunol 2002
:
In contrast, IL-12 induced FasL transcription to lead to FasL expression on the surfaces of nonadherent bone marrow cells, whereas
TNF-alpha could not
induce FasL on the cells
Misseri et al., American journal of physiology. Renal physiology 2005
(Inflammation...) :
Renal obstruction
induced increased tissue TNF-alpha and
Fas ligand mRNA levels, TNF-alpha protein production, apoptotic renal tubular cell death, and elevated caspase 8 and 3 activity, whereas treatment with PEG-sTNFR1 significantly reduced obstruction induced
TNF-alpha production, renal tubular cell apoptosis, and caspase activity
Zhou et al., Hepatology 2005
(Hepatitis) :
These in vitro studies demonstrated that
TNF-alpha induces CD40 expression in hepatocytes and that subsequent activation of CD40 results in hepatocyte apoptosis
mediated at least in part by enhanced hepatocyte expression of
FasL
Carmona et al., J Immunol 2006
:
We additionally determined that IL-1beta and
TNF-alpha secretion by beta-glucan stimulated DCs was partially
regulated by
Fas-FasL
Farley et al., J Invest Dermatol 2006
(Dermatitis...) :
In HaCaT cells and in reconstructed human epidermis ( RHE ),
FasL triggered a NF-kappaB dependent mRNA accumulation of inflammatory cytokines (
tumor necrosis factor-alpha , IL-6, and IL-1beta ), chemokines ( CCL2/MCP-1, CXCL1/GROalpha, CXCL3/GROgamma, and CXCL8/IL-8 ), and the adhesion molecule ICAM-1
Kitaura et al., Immunol Lett 2006
:
Furthermore, IL-18 and IL-12 synergistically induced apoptosis of adherent bone marrow cells in the
presence of
TNF-alpha , and up-regulated
FasL transcription in non-adherent cells
Matsuda et al., Int J Oncol 2006
(Disease Models, Animal...) :
We found that mAb treatment activates Kupffer cells to produce inflammatory cytokines such as
TNF-alpha and IL-12, and
induces the expression of
FasL on Kupffer and NKT cells
Chauhan et al., Anticancer Drugs 2007
:
The
Fas-Fas ligand interaction between macrophages and L929 cells increased the expression of Fas associated death domain, and
tumor necrosis factor-tumor necrosis factor receptor 1 interaction between macrophages and L929 cells
increased the expression of tumor necrosis factor receptor associated death domain in L929 cells
Krogerus et al., Transpl Immunol 2008
(Cytomegalovirus Infections) :
CMV enhanced development of CAN was associated with tubular apoptosis and concomitant increase of
TNF-alpha-TNF-R1 , rather than the
FAS-FAS-ligand activation
Cohen et al., Am J Respir Cell Mol Biol 2009
:
In contrast to Thy1 activation,
TNF-alpha and IFN-gamma do not
induce FasL myofibroblast up-regulation
Solarewicz-Madejek et al., Clin Exp Allergy 2009
(Asthma...) :
IFN-gamma and
TNF-alpha up-regulated TNFR1, TNFR2, Fas and membrane
FasL on SMC
Yoshimatsu et al., Bone 2009
:
We previously reported that IL-12 induces apoptosis in bone marrow cells treated with TNF-alpha in vitro via an interaction between
TNF-alpha induced Fas and IL-12 induced
Fas ligand (FasL) , and that, as a result, osteoclastogenesis is inhibited ... These results suggest that IL-12 inhibits TNF-alpha mediated osteoclastogenesis and induces apoptotic changes through an interaction between
TNF-alpha induced Fas and IL-12 induced
FasL , in vivo, via a T cell independent mechanism
Galvão et al., Biol Reprod 2012
:
In late CL cells,
TNF and TNF+IFNG+FASL reduced VEGFR2 mRNA, but
TNF+IFNG+FASL increased TSP1 and CD36 mRNA
Ando et al., J Immunol 1997
(Hepatitis C) :
We also show that the killing of Ag-presenting, sensitive cells is mediated by Fas ligand and
TNF-alpha as well as perforin, although the latter plays a major role in the killing at a low E : T ratio, and that the killing of sensitive bystander cells is primarily
mediated by
Fas ligand and TNF-alpha on CTLs expressed upon specific Ag stimulation, which may be relevant to the bystander lysis by HCV-specific CTLs of uninfected hepatocytes, in which Fas expression is up-regulated
Sata et al., Nat Med 1998
:
TNFalpha regulation of
Fas ligand expression on the vascular endothelium modulates leukocyte extravasation