Gene interactions and pathways from curated databases and text-mining

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PTGS2 — RAC2

Text-mined interactions from Literome

Slice et al., Biochem Biophys Res Commun 2000 : A CRE/ATF element located at -56 was critical for Ras- and Rac induced transactivation of the COX-2 promoter, but was not required for transactivation by Rho
Hahn et al., Biochem J 2002 : Role of Rac and Cdc42 in lysophosphatidic acid mediated cyclo-oxygenase-2 gene expression ... By exclusion of RhoA and non-specific cytoskeletal effects, the results in the present study indicate an important role for Rac and/or Cdc42 in pertussis toxin-sensitive LPA mediated Cox-2 induction
Azim et al., Am J Physiol Lung Cell Mol Physiol 2007 : Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages ... In summary, these data indicate that Rac2 regulates COX-2 expression in BMDM