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HLA-A — IFNG

Text-mined interactions from Literome

Lefebvre et al., Placenta 1999 (Choriocarcinoma) : We show that the HLA-A promoter activity can not be induced by interferon-gamma (IFN-gamma) and that exogenous MHC class II transactivator CIITA is able to induce HLA class I promoter activity in these cells
Hurks et al., Int J Cancer 2000 (Melanoma...) : In OMM-1 cells, IFN-alpha and -gamma increased the expression of HLA-A but did not induce expression of the 2 B alleles, indicating an HLA-B locus-specific loss
Lee et al., Cancer Res 2000 (Neoplasm Metastasis...) : IFN-gamma induced surface class I MHC expression, as well as gene expression of TAP-1, TAP-2, LMP-2, and LMP-7 in the metastatic cells, yet the cells remained resistant to cell lysis induced by CTLs. Interestingly, although in comparison to the primary cells the metastatic cells were resistant to cytolysis, both cell types were susceptible to DNA fragmentation induced by CTLs. Cell fusion between primary and metastatic cancer cells resulted in hybrids that also resisted the cytolytic activity of CTLs
Tanaka et al., Jpn J Cancer Res 2000 (Genital Neoplasms, Female) : Peripheral blood mononuclear cells ( PBMCs ) of HLA-A24 ( + ) patients with gynecologic cancers were found to produce significant levels of interferon-gamma in response to HLA-A24 ( + ) SART3 ( + ) gynecologic cancer cells after having been stimulated three times in vitro with either SART3 ( 109 - 118 ) or SART3 ( 315 - 323 ) peptide
Turnley et al., J Neuroimmunol 2002 : Neurons from SOCS1 null mice expressed class I MHC in response to IFNgamma , while SOCS1 overexpression in glia inhibited MHC induction
Chong et al., J Immunol 2004 (Diabetes Mellitus, Type 1...) : Additionally, IFN-gamma induced class I MHC up-regulation and TNF- and IFN-gamma induced IL-15 expression by beta cells were inhibited by SOCS-1, which correlated with suppressed 8.3 T cell proliferation in vitro
Sibille et al., Eur J Immunol 1992 : Our data suggests that IFN-gamma reestablishes class I MHC surface expression by restoring access of endogenously synthesized peptide to class I molecules
Willemsen et al., J Immunol 2005 (Melanoma) : Human scFv-G8 ( POS ) T lymphocytes comprising the gamma + CD28 vs the gamma signaling element alone produced substantially more IL-2, TNF-alpha, and IFN-gamma in response to HLA-A1/MAGE-A1 ( POS ) melanoma cells
Bono et al., Res Immunol 1991 : It has previously been shown that stimulation of class I MHC antigen expression by human interferon gamma ( Hu-IFN gamma ) depends on the presence of both human chromosomes 6 and 21 ... Only the hybrid containing the human chromosome 21 ( GM08-gamma R.9 ) exhibited a biological response when assayed for the stimulation of murine class I MHC antigen expression by Hu-IFN gamma
Browne et al., J Immunol 2006 : As shown previously, IFN-gamma controls HLA-A expression primarily at the posttranscriptional level ... Stimulation of HLA-A expression by IFN-gamma requires nuclear export of HLA-A mRNA by chromosome maintenance region 1 ( CRM-1 ) ... Treatment of cells with leptomycin B, a specific inhibitor of CRM-1, completely inhibited IFN-gamma induction of HLA-A ... Increased expression of HLA-A induced by IFN-gamma also requires protein methylation, as shown by the fact that treatment of SK-N-MC cells or HeLa cells with the PRMT1 inhibitor 5'-methyl-5'-thioadenosine abolished the cellular response to IFN-gamma ... These results provide proof of principle that it is possible to differentially modulate the IFN-gamma induced expression of the HLA-E and HLA-A genes, whose products often mediate opposing effects on cellular immunity to tumor cells, pathogens, and autoantigens
Hakem et al., J Immunol 1991 : The transcription of HLA-A3 and HLA-B7 class I genes is differentially regulated by IFN-alpha and -gamma , the latter gene being more inducible than the former
Carlsson et al., Prostate 2007 (Adenocarcinoma...) : However, the HLA-A2 expression level is low and only MCF-7 upregulates HLA-A2 in response to IFN-gamma stimulation
Moyer et al., Exp Cell Res 1992 (Autoimmune Diseases...) : The cells do not express Class I MHC antigens ; however, IFN-beta and IFN-gamma stimulate Class I MHC expression after 24 h, which induces lysis of virus infected cloned endothelium by Class I-restricted virus primed T cells
Otsuka et al., Immunopharmacol Immunotoxicol 1991 (Diabetes Mellitus, Experimental) : Human recombinant IFN-gamma ( 100 U/ml ) increased the expression of HLA-A , B,C molecules, and induced the expression of HLA-DR molecules and, to a lesser extent, of HLA-DP on both HUVEC and HDF
Hinrichs et al., Mol Immunol 2009 : Stimulation with IFN-gamma and/or TNF-alpha led to an increase of HLA-A*3014L secretion to a detectable level and increased HLA-A*3001 expression up to 8-fold, but did not show any difference in the increase of mRNA levels between HLA-A*3014L and A*3001
Isa et al., PloS one 2010 : Quantitative real-time RT-PCR showed that IFNgamma induced a 9-42 fold increase of all six HLA-A , -B, -C gene transcripts
Rich et al., J Interferon Res 1990 : These results are discussed with regard to the further study of AKR SL3 to better understand IFN-gamma regulation of class I MHC expression
Niederwieser et al., J Immunol 1988 : IFN-gamma induces, as expected, a strong increase in class I MHC Ag expression as well as de novo expression of class II MHC Ag, whereas IFN-alpha 2 only slightly increases class I MHC Ag and does not induce keratinocytes to express class II MHC Ag
Yoshioka et al., Liver 1989 : These findings suggest that IFN alpha, IFN gamma , and TNF alpha may play similar roles in enhancement of HLA-A , B, C expression of hepatocytes in hepatitis and hepatoma cells
Takemura et al., Exp Hematol 1989 (Leukemia, Myeloid) : These results indicate that class I MHC antigen expression on K562 cells can be induced by IFN-gamma in cooperation with TNF in a manner different from myeloid antigen expression
Campbell et al., Diabetes 1986 (Adenoma, Islet Cell...) : Expression of class I MHC proteins on RIN-m5F cells is increased by interferon-gamma and lymphokine conditioned medium
Andrews et al., Cancer Res 1987 (Cell Transformation, Viral...) : However, developmental regulation of responsiveness to IFN was evident, since IFN-gamma induced higher levels of surface expression of HLA-A , B, C and beta 2-microglobulin in the retinoic acid induced differentiated NTERA-2 cl.D1 cells than in the undifferentiated parental cells
Campbell et al., J Clin Endocrinol Metab 1986 (Insulinoma...) : Interferon-gamma induces the expression of HLA-A , B,C but not HLA-DR on human pancreatic beta-cells ... The up-regulation of HLA-A , B,C protein on beta-cells by IFN gamma provides a mechanism for enhanced targetting to the beta-cells of autoreactive cytotoxic T-lymphocytes and, hence, for amplifying beta-cell destruction
Green et al., J Immunol 1986 (Leukemia, Experimental) : The results presented here indicate that recombinant murine interferon-gamma can cause a dramatic differential induction of two distinct class I MHC molecules
Hirayama et al., Neurosci Lett 1986 : We studied whether the human IFN-gamma could induce the expression of Human Leukocyte Antigen (HLA)-A , B, C and -DR antigens on cultured human glia from autopsied brain white matter tissue
Wedgwood et al., Cell Immunol 1988 : Similarly, IFN-gamma increases the expression of class I MHC molecules two- to fivefold
Blanar et al., Proc Natl Acad Sci U S A 1988 : IFN-gamma induced transcription of HLA-DR alpha and of the invariant chain gene was blocked by treatment with cycloheximide, but IFN-gamma induced transcription of HLA-A2 was unaffected
Houghton et al., J Exp Med 1984 (Astrocytoma...) : In contrast, three tumor types, teratocarcinoma, choriocarcinoma, and neuroblastoma, were not inducible for Ia expression, even though IFN-gamma could induce expression of HLA-A , B,C products
Satoh et al., Neurology 1995 : Furthermore, IFN-beta significantly reduced IFN-gamma induced expression of class II MHC antigen but not of class I MHC antigen or of ICAM-1
Ritter et al., Immunology 1994 : In spite of the minimal effect of IFN-gamma and no effect of IFN-alpha on class I MHC expression, pretreatment of target cells with both cytokines considerably increased their lytic susceptibility
Thomas et al., J Clin Invest 1998 (Diabetes Mellitus, Type 1) : IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes ... This study dissociates class I MHC upregulation from progression to diabetes, shows that the rise in class I MHC is due to local IFN-gamma action, and eliminates beta cells as the targets of IFN-gamma in autoimmune diabetes