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IFNG — IL17A

Text-mined interactions from Literome

Albanesi et al., J Immunol 2000 (Calcium Signaling...) : IL-4, but not IL-10 or IL-17 , significantly up-regulated IFN-gamma- or TNF-alpha induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants
Lenarczyk et al., Clin Exp Immunol 2000 : We therefore investigated the in vitro IL-17 response to a variety of mitogens and antigens, and compared the IL-17 response to interferon-gamma (IFN-gamma) , IL-4, IL-10 and TNF-alpha
Andoh et al., Clin Exp Immunol 2001 : IFN-gamma induced a weak increase in IL-17 R mRNA abundance, and incubation with IFN-gamma for 24 h enhanced [ ( 125 ) I ] -labelled IL-17 binding by 2.4-fold
Park et al., Nat Immunol 2005 (Inflammation...) : Furthermore, both IL-4 and interferon-gamma negatively regulated T helper cell production of IL-17 in the effector phase
Komiyama et al., J Immunol 2006 (Encephalomyelitis, Autoimmune, Experimental) : Notably, IL-17 producing T cells were increased in IFN-gamma ( -/- ) cells, while IFN-gamma producing cells were increased in IL-17 ( -/- ) cells, suggesting that IL-17 and IFN-gamma mutually regulate IFN-gamma and IL-17 production
Kullberg et al., J Exp Med 2006 (Colitis...) : Although IL-23 has been implicated in the differentiation of IL-17 producing CD4+ T cells that alone are sufficient to induce autoimmune tissue reactivity, our results instead support a model in which IL-23 drives both interferon gamma and IL-17 responses that together synergize to trigger severe intestinal inflammation
Chi et al., J Allergy Clin Immunol 2007 (Uveomeningoencephalitic Syndrome) : Recombinant IL-23 significantly enhanced IL-17 production, whereas rIL-12 and IFN-gamma inhibited IL-17 production
Chu et al., Arthritis Rheum 2007 (Arthritis, Experimental...) : We undertook this study to test the hypothesis that resistance to collagen induced arthritis ( CIA ) in C57BL/6 ( B6 ) mice is regulated by IFNgamma mediated suppression of IL-17
Annunziato et al., J Exp Med 2007 : Interestingly, these subsets also expressed the Th1-transcription factor T-bet, and stimulation of these cells in the presence of IL-12 down-regulated the expression of ROR gamma t and the production of IL-17 , but induced IFN-gamma
Irmler et al., J Immunol 2007 (Acute Disease...) : In vitro, Th cell expansion and production of IL-17 upon restimulation were effectively and dose dependently inhibited by IFN-gamma
Molesworth-Kenyon et al., J Leukoc Biol 2008 (Keratitis, Herpetic) : Infection of IFN-gamma gene knockout mice was associated with elevated IL-17 levels and accelerated corneal opacity, suggesting that IFN-gamma negatively regulated IL-17 expression ... Collectively, our results establish that IL-17 is rapidly produced in the cornea after HSV-1 infection and is regulated at least in part by IFN-gamma
Hirota et al., J Exp Med 2007 (Arthritis, Experimental...) : The CCL20 production by synoviocytes is augmented in vitro by IL-1beta, IL-17 , or tumor necrosis factor alpha, and is suppressed by IFN-gamma or IL-4
Yusuf et al., Cancer Res 2008 (Dermatitis, Contact...) : Interestingly, the cell mediated immune response was mediated by IFN-gamma in C3H/HeN mice and by interleukin (IL)-17 in C3H/HeJ mice
Scriba et al., J Immunol 2008 (Tuberculosis, Pulmonary) : IL-17 was not detected in this fluid, which may be due to suppression by Th1 cytokines, as PBMC IL-17 production was inhibited by IFN-gamma in vitro
Mauermann et al., Am J Respir Crit Care Med 2008 (Disease Models, Animal...) : Mechanistically, the absence of IFN-gamma or IFN-gamma signaling in pulmonary parenchymal cells promoted expansion of IL-17A producing CD4 ( + ) T cells and local IL-17A release
Yang et al., Br J Ophthalmol 2009 (Uveomeningoencephalitic Syndrome) : RAPA was able to completely inhibit IL-17 production at a dosage of 10 ng/ml but only partially suppressed IFN-gamma production even at a much higher concentration ( 1000 ng/ml )
Eyerich et al., J Allergy Clin Immunol 2009 (Dermatitis, Atopic...) : In vivo, additional application of staphylococcal enterotoxin B induced IL-17 in APT reactions, whereas IL-4, IFN-gamma , and IL-10 were marginally regulated
Satpute et al., Arthritis Rheum 2009 (Arthritis, Experimental) : The production of interferon-gamma ( but not IL-4/IL-10 ) was increased , with concurrent down-regulation of IL-17 expression by mycobacterial Hsp65 primed T cells
Boomsma et al., Reprod Biomed Online 2009 (Infertility, Female) : Heparin binding epidermal growth factor, IL-5, IL-17 , IL-10, Dickkopf homologue-1 and IL-15 were detected in 23-76 %, whereas interferon-gamma was not detectable in any of the samples
Veenbergen et al., Ann Rheum Dis 2010 (Arthritis, Experimental) : No significant differences were observed in anti-BCII antibodies, but the aggravation was accompanied by decreased IFNgamma ( -30 % ) and IL-4 ( -44 % ) and increased IL-17 ( +84 % ) production by splenic CD3 ( + ) T cells
Lemos et al., Proc Natl Acad Sci U S A 2009 (Arthritis, Rheumatoid...) : Our results suggest that prostaglandin plays an important role in IL-23 induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNgamma production
Zdravkovic et al., Mol Immunol 2009 (Diabetes Mellitus, Experimental) : RT-PCR analysis of mRNA transcripts of diabetogenic cytokines revealed that the expression of TNF-alpha, and IFN-gamma was significantly enhanced in pancreatic lymph nodes by day 10 after diabetes induction in ST2-deficient mice in comparison with wild type BALB/c mice while IL-17 was detected only in ST2 ( -/- ) mice by day 21
Nakagome et al., J Immunol 2009 (Respiratory Hypersensitivity) : Moreover, IFN-gamma also suppressed the production of IL-17 and IFN-gamma itself
Yi et al., Blood 2009 (Graft vs Host Disease...) : However, absence of interferon-gamma (IFN-gamma) in CD4 ( + ) T cells resulted in augmented Th2 and Th17 differentiation and exacerbated tissue damage in lung and skin ; absence of both IL-4 and IFN-gamma resulted in augmented Th17 differentiation and preferential, although not exclusive, tissue damage in skin ; and absence of both IFN-gamma and IL-17 led to further augmentation of Th2 differentiation and idiopathic pneumonia
Sarkar et al., Arthritis Res Ther 2009 (Arthritis, Experimental...) : The goals of this study were to determine the relationship between Th17 responses and disease severity in CIA and to assess regulation of IL-17 by endogenous IFN-gamma and IL-4
Lin et al., Immunity 2009 (Tularemia) : Furthermore, we show that IL-17A also induced IL-12 and interferon-gamma production in macrophages and mediated bacterial killing
Doodes et al., J Immunol 2010 (Arthritis, Experimental...) : IFN-gamma regulates the requirement for IL-17 in proteoglycan induced arthritis ... In the current study, we investigated the effect of IFN-gamma on the IL-17 response and its consequences in PGIA
Tournadre et al., Arthritis Rheum 2010 (Dermatomyositis...) : Stimulation with interferon-gamma (IFNgamma) increased TLR-3 mRNA levels, but IL-17 down-regulated the inducing effect of IFNgamma
Murugaiyan et al., Proc Natl Acad Sci U S A 2010 (Encephalomyelitis, Autoimmune, Experimental) : Here, we show that IFN-gamma induces IL-27 while inhibiting OPN expression in DCs both in vitro and in vivo and that engagement of IFN-gammaR expressed by DCs leads to suppression of IL-17 production while inducing IL-10 from T cells
Albanesi et al., J Immunol 1999 : In contrast, IFN-gamma- and TNF-alpha induced production of RANTES was markedly inhibited by IL-17 , and the synthesis of macrophage chemotactic protein 1 was not changed