◀ Back to IL1B
CASP1 — IL1B
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IL1B
→
CASP1
(increases, IL1B Activity)
Evidence: from full text - Increased levels of IL-1 in IBD may be result of stimulation of colonic macrophages that can activate interleukin (IL)-1 converting enzyme (ICE) and hence release mature IL-1beta into the colonic mucosa[20].
-
OpenBEL Selventa BEL large corpus:
IL1B
→
CASP1
(increases, IL1B Activity)
Aliprantis et al., EMBO J 2000*
Evidence: Interestingly, BLP also activates caspase 1 through TLR2, resulting in proteolysis and secretion of mature IL-1beta.
-
OpenBEL Selventa BEL large corpus:
IL1B
→
CASP1
(increases, IL1B Activity)
Evidence: We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for the endogenous caspase-1 inhibitory activity in human SMCs and prevents processing of the enzyme's natural substrates, IL-1beta and IL-18 precursor.
-
KEGG Influenza A:
CASP1
→
IL1B
(protein-protein, activation)
-
NCI Pathway Database IL1-mediated signaling events:
Caspase 1 (cleaved) (CASP1/CASP1)
→
IL1 beta (IL1B)
(modification, activates)
Symons et al., Proc Natl Acad Sci U S A 1995*, Wilson et al., Nature 1994*
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL1-mediated signaling events:
Caspase 1 (cleaved) (CASP1/CASP1)
→
IL1 beta fragment (IL1B)
(modification, activates)
Symons et al., Proc Natl Acad Sci U S A 1995*, Wilson et al., Nature 1994*
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL1-mediated signaling events:
Caspase 1 (cleaved) (CASP1/CASP1)
→
IL1 beta/IL1R2 complex (IL1B-IL1R2)
(modification, activates)
Symons et al., Proc Natl Acad Sci U S A 1995*, Wilson et al., Nature 1994*
Evidence: mutant phenotype, assay
-
NCI Pathway Database IFN-gamma pathway:
IL1 beta (IL1B)
→
Caspase 1 (tetramer) complex (CASP1)
(modification, collaborate)
Joshi et al., J Interferon Cytokine Res 2006*
Evidence: mutant phenotype, other species
-
NCI Pathway Database Cellular roles of Anthrax toxin:
IL1 beta (IL1B)
→
Caspase 1 (tetramer) complex (CASP1)
(modification, collaborate)
Fantuzzi et al., J Clin Immunol 1999*
-
Reactome Reaction:
CASP1
→
IL1B
(reaction)
Thornberry et al., Nature 1992*, Gu et al., Science 1997*, Ghayur et al., Nature 1997*
-
WikiPathways Nucleotide-binding Oligomerization Domain (NOD) pathway:
CASP1
→
IL1B
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
IL1B
—
CASP1
(direct interaction, enzymatic study)
Gu et al., J Biol Chem 1995*
-
IRef Hprd Interaction:
CASP1
—
IL1B
(in vivo)
Howard et al., J Immunol 1991*, Kamens et al., J Biol Chem 1995*
-
IRef Hprd Interaction:
CASP1
—
IL1B
(in vitro)
Howard et al., J Immunol 1991*, Kamens et al., J Biol Chem 1995*
-
IRef Innatedb Interaction:
CASP1
—
IL1B
(unknown, -)
Ghayur et al., Nature 1997*
-
IRef Ophid Interaction:
CASP1
—
IL1B
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pirhonen et al., J Immunol 1999
:
Since caspase-1 is known to cleave proIL-1 beta and proIL-18 into their mature, active forms, we analyzed the
effect of a specific
caspase-1 inhibitor on virus induced
IL-1 beta and IL-18 production ... Furthermore, the virus induced activation of
caspase-1 is
required for the efficient production of biologically active
IL-1 beta and IL-18
Stosić-Grujicić et al., Clin Lab Haematol 1999
(Acute Disease...) :
The presence of IL-1Ra or antisense
ICE also
suppressed the endogenous
IL-1 beta production of AML cells, at both the level of pro-IL-1 beta and mature IL-1 beta
Zeuner et al., Cell Death Differ 1999
:
In addition to the well established
role of
caspase-1 in the production of active
IL-1beta and IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis
Laliberte et al., J Biol Chem 1999
:
Characterization of the pharmacological sensitivity of this stimulus coupled response revealed that some
caspase-1 inhibitors
allow pro-IL-1beta secretion, whereas others do not
Moldovan et al., Osteoarthritis Cartilage 2000
(Osteoarthritis) :
Diacerhein and rhein reduce the
ICE induced
IL-1beta and IL-18 activation in human osteoarthritic cartilage
Sansonetti et al., Immunity 2000
(Dysentery, Bacillary...) :
Caspase-1 activation of
IL-1beta and IL-18 are essential for Shigella flexneri induced inflammation
Humke et al., Cell 2000
:
ICEBERG is a novel protein that
inhibits generation of
IL-1beta by interacting with
caspase-1 and preventing its association with RIP2
Mehta et al., J Biol Chem 2001
:
Neither
IL-1beta nor IL-18 release was prevented by ICE inhibition, and IL-18 release was not
induced by
ICE activation itself
Nonaka et al., J Periodontal Res 2001
:
IL-1beta secretion was
blocked by the
caspase-1 inhibitor, Z-VAD-FMK, indicating that caspase-1 is involved in not only the induction of apoptosis but also the IL-1beta secretion from A. actinomycetemcomitans infected J774.1 cells
Lee et al., J Biol Chem 2001
:
The production of bio-active
interleukin-1beta (IL-1beta) , a pro-inflammatory cytokine, is
mediated by activated
caspase-1
Carpenter et al., Diabetes 2002
:
That
IL-1beta also
activated caspase-3 and promoted PKCdelta cleavage suggests that this distal pathway also contributes in the apoptotic response to the cytokine
Lynch et al., Eur J Neurosci 2002
(MAP Kinase Signaling System) :
Analysis of colocalization of activated caspase-3 with activated p38 ( p-p38 ) suggested that p-p38 was necessary for activation of caspase-3 ; while in vitro analysis indicated that the
IL-1beta induced increase in
caspase-3 activity was abrogated by the p38 inhibitor, SB203580 ... The
IL-1beta induced increase in
caspase-3 activity in vitro was also abrogated by vasoactive intestinal peptide, which is a JNK inhibitor ; however, colocalization of activated JNK ( p-JNK ) and activated caspase-3 did not clearly identify JNK as an upstream activator of caspase-3
Martinon et al., Mol Cell 2002
(Inflammation) :
Generation of Interleukin
(IL)-1beta via cleavage of its proform
requires the activity of
caspase-1 ( and caspase-11 in mice ), but the mechanism involved in the activation of the proinflammatory caspases remains elusive
Schauvliege et al., J Biol Chem 2002
:
Murine
caspase-11 , together with caspase-1, is
essential for the production of
IL-1beta in response to lipopolysaccharide (LPS)
Kang et al., Cell Death Differ 2002
(Disease Models, Animal...) :
The early activation of caspases-3/-7 by
caspase-11 was not
affected by blocking of caspase-1 activity and
IL-1beta release, implying that caspase-11 activates caspases-3/-7 independently of caspase-1 activation
Suschek et al., Mol Pharmacol 2002
:
Because
ICE activity is
essential for the endogenous synthesis of active
IL-1beta , ICE overexpression represents the key signal in the AmB induced and IL-1beta mediated effects on iNOS activity
Evans et al., Gastroenterology 2002
(Inflammatory Bowel Diseases) :
In peripheral blood mononuclear cells, inhibition of
caspase 1
reduced interleukin-1beta secretion, whereas blockade of phagocytosis inhibited calcium induced apoptosis and
interleukin-1beta release
Yoo et al., Biochem Biophys Res Commun 2002
:
The production of bioactive
interleukin-1beta (IL-1beta) , a pro-inflammatory cytokine, is
mediated by activated
caspase-1 ... Nod1 enhances
caspase-1 induced
IL-1beta secretion, as well as lipopolysaccharide (LPS) induced IL-1beta secretion in transfected cells
Wang et al., Br J Pharmacol 2003
(Hypercholesterolemia...) :
8. This study demonstrates that injection of a selective caspase-1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia-reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of
IL-1beta production and
activation of
caspase-1 and caspase-3
Stuyt et al., Cytokine 2003
:
Inhibition of
caspase-1 reduced IFN-gamma and
IL-1beta levels ( by 80 and 67 %, respectively ) when heat killed S. epidermidis was added to whole human blood cultures
Jendrossek et al., Infect Immun 2003
:
In addition, only the piliated wild-type strains induced
caspase-1 mediated activation of
interleukin-1 beta
Stehlik et al., J Biol Chem 2003
:
In contrast to its effects on Nod1- and Cardiak dependent NF-kappa B activation, CARD6 did not interfere with
caspase-1 dependent
interleukin-1 beta secretion induced by Cardiak or Nod1
Chen et al., Biochem Pharmacol 2003
:
Novel roles for palmitoylation of Ras in
IL-1 beta induced nitric oxide release and
caspase 3 activation in insulin secreting beta cells ... CER-treatment also prevented
IL-1 beta induced activation of
caspase 3 in these cells
Fortunato et al., Placenta 2003
:
When compared to control,
IL-1 beta increased
caspase 2, 3, 8 and 9 activities, whereas IL-6 treated membranes did not exhibit a significant change
Shiratsuch et al., Am J Surg 2003
:
Caspase-1 inhibition significantly
reduced IL-1beta production by SmT- and SmD infected monocytes ( P < 0.05, n = 4 )
Donnelly-Roberts et al., J Pharmacol Exp Ther 2004
(MAP Kinase Signaling System) :
Two
caspase inhibitors, YVAD ( caspase 1 ) and DEVD ( caspase 3 ),
attenuated both BzATP induced pore formation and
IL-1beta release in a concentration dependent fashion ... In contrast, P2X(7)R mediated
IL-1beta release is
dependent on
caspase activity but not p38 MAPK
Veluthakal et al., Am J Physiol Cell Physiol 2004
:
N ( G ) -monomethyl-l-arginine, a known inhibitor of inducible nitric oxide synthetase (iNOS), markedly inhibited
IL-1beta induced iNOS gene expression, NO release,
caspase-3 and caspase-6 activation, lamin B degradation, and loss of metabolic cell viability, indicating that the observed IL-1beta induced effects on nuclear lamin B involve the intermediacy of NO
Papaccio et al., J Cell Physiol 2005
:
Our data have evidenced the following : ( i ) addition of Efaroxan to islet cultures inhibited
IL-1beta activation of
ICE ( cysteine protease IL-1beta converting enzyme ) while addition of 1400W did not ; ( ii ) Efaroxan completely inhibited IL-1beta induced suppression of insulin secretion and induction of iNOS mRNA transcripts, and, in addition, counteracted islet beta-cell protein profile alterations, Bax-cytochrome c translocation, caspase activation, and apoptosis ; ( iii ) 1400W inhibited IL-1beta induction of iNOS, but failed to completely counteract the other cytotoxic effects ; ( iv ) the two compounds, moreover, exerted different effects on manganese superoxide dismutase ( MnSOD ), in fact, while Efaroxan inhibited the early stimulatory effect of IL-1beta on MnSOD, 1400W did not
Basak et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1 mediated
caspase-1 activation
play essential roles in
interleukin-1beta release from Helicobacter pylori lipopolysaccharide stimulated macrophages
Cooke et al., Transplantation 2005
:
In addition, AdvBcl-2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft
IL-1beta production and
inhibited intragraft
caspase-3 and caspase-9 activity
Ubol et al., Microbiol Immunol 2005
(Disease Models, Animal...) :
The first is immune mediated death which may operate through the receptor-ligand pathway
activated by
caspase-1 and the pro-inflammatory cytokine,
IL-1beta
Wang et al., Ann Thorac Surg 2005
(Reperfusion Injury) :
Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor,
interleukin-1beta and interleukin-6, and
activation of caspase-1,
caspase-3 and caspase-11
El Btaouri et al., Biochem Biophys Res Commun 2006
(MAP Kinase Signaling System) :
The permeable exogenous C ( 2 ) -ceramide reproduces
IL-1beta effects on: (i) inhibition of adenylyl cyclase activity, ( ii ) down-regulation of ERK1/2 phosphorylation, ( iii ) activation of
caspase-3 , and ( iv ) apoptosis in pig thyroid cells
Shakibaei et al., Ann Anat 2005
:
Additionally, curcumin antagonized
IL-1beta induced
caspase-3 activation in a time dependent manner
Okemoto et al., J Immunol 2006
:
A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of
IL-1beta or
activation of
caspase-1
Yao et al., J Biol Chem 2006
:
By incubation with mK13, but not with mK1, mK9, or mK22, the 35-kDa
pro-IL-1beta was cleaved into two major products with molecular masses of 17.5 and 22 kDa, and production was
inhibited by phenylmethylsulfonyl fluoride, a serine protease inhibitor, but not by
IL-1beta converting enzyme inhibitors
MacRae et al., J Endocrinol 2006
:
TNFalpha but not
IL-1beta exposure
led to increased
caspase-3 activity and altered cellular morphology, consistent with reduced viability
Zhang et al., J Gastroenterol Hepatol 2006
:
Enhancement of
IL-1beta protein release induced by hyperosmotic stress was significantly
attenuated by an
ICE inhibitor, Z-YVAD-FMK
Raupach et al., Infect Immun 2006
(Salmonella Infections, Animal) :
Caspase-1 mediated
activation of
interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection
Ravizza et al., Epilepsia 2006
(Disease Models, Animal...) :
Caspase-1 inhibition
reduced the release of
IL-1beta in organotypic slices exposed to LPS+ATP
Dorfleutner et al., Infect Immun 2007
(Inflammation) :
cPOP2 binds to ASC and PAN1, thereby blocking formation of cryopyrin and PAN1 containing inflammasomes,
activation of
caspase-1 , and subsequent processing and secretion of bioactive
interleukin-1beta
Rosengren et al., J Allergy Clin Immunol 2007
(Autoimmune Diseases...) :
Caspase-1 inhibitors
prevented the cold induced
IL-1beta release, whereas a purinergic antagonist did not
Dinarello et al., Semin Nephrol 2007
(Inflammation...) :
IL-18 is a member of the IL-1 family ;
IL-1beta and IL-18 are related closely, and both
require the intracellular cysteine protease
caspase-1 for biological activity
Boost et al., Intensive Care Med 2007
(Endotoxemia) :
Targeting
caspase-1 by inhalation-therapy :
effects of Ac-YVAD-CHO on
IL-1 beta , IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
Shakibaei et al., Ann N Y Acad Sci 2007
:
Resveratrol inhibits
IL-1 beta induced stimulation of
caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
Ikeda et al., J Immunol 2007
(MAP Kinase Signaling System) :
The release of UA-induced
IL-1beta was significantly
inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP binding cassette transporter, and
caspase-1
Li et al., J Immunol 2007
:
Aluminum hydroxide adjuvants activate
caspase-1 and
induce IL-1beta and IL-18 release
Dinarello et al., Immunity 2007
(Inflammation) :
Secretion of the proinflammatory cytokine
IL-1beta requires
caspase-1 and Toll-like receptor ( TLR ) signaling
Ahmed et al., J Vet Med Sci 2007
:
However, leptin treatment increased monocyte/macrophages production of
IL-1beta as well as TNF-alpha, and
induced the mRNA expression of
caspase-1 , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms
Moore et al., Synapse 2007
(Disease Models, Animal...) :
In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the
IL-1beta induced increases in activation of JNK and
caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3
Schroeder et al., Microbiology 2007
:
Addition of CCCP 15 min after infection blocked macrophage cell death, the
activation of
caspase-1 and the maturation of
IL-1beta , without affecting uptake or escape of S. flexneri from the phagosome
Holohan et al., J Cell Mol Med 2008
(Insulinoma) :
The broad range
caspase inhibitor, Boc-D-fmk,
blocked IL-1beta/IFNgamma -induced caspase activity, but not nitric oxide production nor cell death
Galle et al., J Cell Mol Med 2008
(Pseudomonas Infections) :
Altogether, these data demonstrate a dual role for the P. aeruginosa T3SS in the regulation of
Caspase-1 mediated
IL-1beta production and provide new insights into the mechanisms of immune evasion by this pathogen
Kuijk et al., Mol Immunol 2008
:
Statin synergizes with LPS to
induce IL-1beta release by THP-1 cells through activation of
caspase-1 ... Taken together, these results demonstrate that simvastatin
augments LPS induced
IL-1beta release post-translationally, by inducing
caspase-1 activity
Miao et al., Proc Natl Acad Sci U S A 2008
:
We demonstrate here that Pseudomonas aeruginosa activates
caspase 1 and
induces IL-1beta secretion in infected macrophages
Rupper et al., Infect Immun 2008
:
The activation of
caspase-1 by the detection of bacterial products through Nod-like receptors
leads to the secretion of mature
interleukin-1beta (IL-1beta) and IL-18 and the induction of rapid host cell death ( pyroptosis )
Gustavsson et al., Retina 2008
(Diabetes Mellitus, Experimental...) :
Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ),
IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes
induced increased expression of
caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Coppola et al., Int J Biochem Cell Biol 2008
:
In beta-TC3 cells, NT activates both MAP and PI-3 kinases pathways and strongly reduces the staurosporine or the
Il-1beta induced
caspase-3 activity by a mechanism involving Akt activation
Pelegrin et al., J Immunol 2008
:
We delineated two distinct release pathways : the well-known caspase-1 cascade mediating release of processed
IL-1beta that was selectively
blocked by inhibition of
caspase-1 or panx1, and a calcium independent, caspase-1/panx1 independent release of pro-IL-1beta that was selectively blocked by glycine
Kang et al., Eur J Immunol 2008
(Anthrax) :
In contrast, we now report that
caspase-1 mediated
IL-1beta expression in response to BA spores is required for anti-BA host defenses
Hsu et al., Proc Natl Acad Sci U S A 2008
(Anthrax...) :
A NOD2-NALP1 complex mediates
caspase-1 dependent
IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
Hewinson et al., J Immunol 2008
(Ion Channel Gating) :
Inflammatory
caspase-1 is
responsible for the proteolytic activation of
IL-1beta
Yajima et al., Circulation 2008
(Inflammation...) :
Apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates
caspase-1 dependent
IL-1 beta and IL-18 generation ; however, the role of ASC in vascular injury remains undefined
Li et al., J Immunol 2008
(Inflammation) :
We have recently shown that alum activates
caspase-1 and
induces secretion of mature
IL-1beta and IL-18
Shakibaei et al., Biochem Pharmacol 2008
(Osteoarthritis) :
Furthermore, we observed that resveratrol as well as ALLN inhibited
IL-1beta induced apoptosis,
caspase-3 activation and PARP cleavage in human articular chondrocytes
Kuijk et al., Blood 2008
(Mevalonate Kinase Deficiency) :
HMG-CoA reductase inhibition
induces IL-1beta release through Rac1/PI3K/PKB dependent
caspase-1 activation ...
IL-1beta release is
mediated by
caspase-1 , and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner
Maelfait et al., J Exp Med 2008
(Inflammation) :
These results implicate a novel
role for
caspase-8 in the production of biologically active
IL-1beta in response to TLR3 and TLR4 stimulation
González-Benítez et al., Mediators Inflamm 2008
(Inflammation) :
In the inflammosome complex, NALP3 or NALP1 binds to ASC and activates
caspase-1 which
induces IL-1beta
Deng et al., Toxicol Appl Pharmacol 2009
(Periodontitis) :
Furthermore, caspase-1, a promoter of IL-1beta production, was activated by treatment with alendronate, and
caspase-1 inhibitor
reduced the production of
IL-1beta induced by alendronate and P. gingivalis
Wang et al., Stroke 2009
(Brain Ischemia...) :
Mitochondrial membrane potential, release of apoptogenic mitochondrial factors,
pro-IL-1beta processing, and
activation of
caspase -1 and -3 were evaluated ... Methazolamide and melatonin inhibit oxygen/glucose deprivation induced cell death, loss of mitochondrial membrane potential, release of mitochondrial factors,
pro-IL-1beta processing, and
activation of
caspase-1 and -3 in primary cerebrocortical neurons
Hise et al., Cell Host Microbe 2009
(Candidiasis...) :
The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription, whereas the NLRP3 containing proinflammatory multiprotein complex, the NLRP3 inflammasome, controls
caspase-1 mediated cleavage of
pro-IL-1beta
Zaiss et al., J Immunol 2009
(Adenoviridae Infections) :
In direct correlation with the increased viral internalization, antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes, type I IFNs, and
caspase dependent
IL-1beta maturation
Talabot-Ayer et al., J Biol Chem 2009
:
Consistently,
caspase-1 activation in THP-1 cells
induced cleavage of
pro-IL-1beta but not of pro-IL-33, and activated THP-1 cells released full-length pro-IL-33 into culture supernatants
Franchi et al., J Immunol 2009
(Inflammation) :
In addition to TNF-alpha, IL-1alpha and
IL-1beta promoted
caspase-1 activation via Nlrp3 in response to ATP
Muñoz-Planillo et al., J Immunol 2009
(Inflammation...) :
In this study, we show that the ability of Staphylococcus aureus, a leading cause of infection in humans, to activate
caspase-1 and
induce IL-1beta secretion resides in culture supernatants of growing bacteria
Cho et al., Infect Immun 2010
:
Bacillus anthracis capsule activates
caspase-1 and
induces interleukin-1beta release from differentiated THP-1 and human monocyte derived dendritic cells ... The extracellular release of
IL-1beta in response to PGA was
ICE dependent , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta
Prantner et al., Infect Immun 2009
(Chlamydia Infections) :
By using LPS primed macrophages as a model system, it was determined that
IL-1beta secretion was
dependent on
caspase-1 , potassium efflux, and the activity of serine proteases
Becker et al., J Biol Chem 2009
:
Rab39a binds
caspase-1 and is
required for caspase-1 dependent
interleukin-1beta secretion
Honsho et al., Circ Res 2009
(Endomyocardial Fibrosis...) :
IL-1beta deficiency markedly
increased c-Jun N-terminal kinase (JNK) and
caspase-3 activities and enhanced myocyte apoptosis and fibrosis, whereas replacement of IGF-1 or JNK inhibitor restored them
Henrotin et al., Osteoarthritis Cartilage 2010
(Inflammation...) :
Curcumin blocks
IL-1beta induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of
caspase-3
Li et al., Pain 2009
(Complex Regional Pain Syndromes...) :
Using this model we observed that : ( 1 ) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, ( 2 ) NALP1, caspase-1 and
IL-1beta were co-expressed in keratinocytes, and the number of NALP1,
caspase-1 , and IL-1beta positive cells dramatically
increased at 4 weeks post-fracture, ( 3 ) LY303870, an NK1 receptor antagonist, effectively blocked fracture induced up-regulation of activated inflammasome components and cytokines, ( 4 ) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and ( 5 ) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture induced hindpaw mechanical allodynia
Clarke et al., Circ Res 2010
(Hyperlipidemias...) :
In contrast, secondary necrotic VSMCs release both IL-1alpha and
caspase activated
IL-1beta , augmenting IL-6 and MCP-1 production
Guma et al., Arthritis Rheum 2009
(Arthritis, Experimental...) :
Caspase 1-independent activation of
interleukin-1beta in neutrophil-predominant inflammation ... The production of
IL-1beta by neutrophils and mast cells is not exclusively
dependent on
caspase 1, and other proteases can compensate for the loss of caspase 1 in vivo
Auerbuch et al., PLoS Pathog 2009
(Yersinia pseudotuberculosis Infections) :
However,
caspase-1 was
required for secretion of the inflammatory cytokine
IL-1beta in response to T3SS positive Y. pseudotuberculosis
Meixenberger et al., J Immunol 2010
:
RNA interference and inhibitor experiments in human PBMCs as well as experiments in Nlrp3 and Rip2 knockout bone marrow derived macrophages demonstrated that the Listeria induced
IL-1beta release was
dependent on ASC,
caspase-1 , and NLRP3, whereas NOD2, Rip2, NLRP1, NLRP6, NLRP12, NLRC4, and AIM2 appeared to be dispensable
Imamura et al., J Immunol 2010
(Shock, Septic) :
Interestingly, the NOD of human PYNOD was sufficient to inhibit caspase-1 mediated IL-1beta secretion, whereas its pyrin domain was sufficient to inhibit ASC mediated NF-kappaB activation and apoptosis and to reduce ASC 's ability to promote
caspase-1 mediated
IL-1beta production
Bauer et al., Gut 2010
(Colitis...) :
Macrophages incubated with DSS in vitro secreted high levels of
IL-1beta in a
caspase-1 dependent manner
Dinarello et al., Expert Rev Clin Immunol 2005
:
IL-18 is a member of the IL-1 family ;
IL-1beta and IL-18 are closely related, and both
require the intracellular cysteine protease
caspase-1 for biologic activity
Dinarello et al., Curr Opin Endocrinol Diabetes Obes 2010
(Diabetes Mellitus, Type 2...) :
Caspase-1 is
required for
IL-1beta activity and the release of free fatty acids from the adipocyte
Zitta et al., Biochem Biophys Res Commun 2010
(Myocardial Infarction) :
Gene expression of
caspase-3 was
increased by
IL-1beta ( P < 0.05 vs. control ; 100ng/ml ; 3h ), and pro-caspase-3 but not active caspase was detected in lysates of pig heart cells by Western blotting
Kotrange et al., J Leukoc Biol 2011
(Burkholderia Infections) :
Burkholderia cenocepacia O polysaccharide chain contributes to
caspase-1 dependent
IL-1beta production in macrophages
Li et al., Cell 1995
(Shock, Septic) :
ICE therefore
plays a dominant role in the generation of mature
IL-1 beta , a previously unsuspected role in production of IL-1 alpha, but has no autonomous function in apoptosis
Chin et al., J Immunol 1993
:
Conversely, the
IL-1 beta converting enzyme inhibitor, Ac-Tyr-Val-Ala-Asp-CHO ( L-709,049 ) and the anti-inflammatory agent [ 5- ( 4-pyridyl ) 6 ( 4-fluorophenyl ) -2,3-dihydroimidazo ( 2,1-b ) thiazole ] ( SK & F 86002 )
inhibited IL-1 beta release in both the standard and staged release assays with IC50 of 1 microM
Mundle et al., Blood 1996
(Lymphoma, Non-Hodgkin...) :
On the other hand, a specific tetrapetide-aldehyde inhibitor of
ICE significantly retarded the apoptotic death of BMAM cells at 1 mumol/L in 5/6 MDS cases studied ( AI % = 2.99 +/- 0.30 in controls v 1.58 +/- 0.40 with ICE-inhibitor, P = .05 ) and also
reduced the levels of active
IL-1 beta synthesized ( 5.59 +/- 2.63 v 2.24 +/- 0.93 pg/10 ( 6 ) cells, respectively )
Estrov et al., Leukemia & lymphoma 1997
(Leukemia, Myeloid, Acute) :
It was therefore hypothesized that
ICE may either
augment the production of mature
IL-1 beta and stimulate the proliferation of cells, in which IL-1 beta acts as an autocrine growth factor, or induce apoptosis ... Because IL-1 beta serves as either an autocrine or paracrine growth factor in AML, we recently investigated the effect of ICE inhibition on AML colony growth and found that
ICE inhibition
reduced the production of mature
IL-1 beta and suppressed AML progenitor proliferation
Ghayur et al., Nature 1997
:
A selective
caspase-1 inhibitor
blocks both lipopolysaccharide induced
IL-1beta and IFN-gamma production from human mononuclear cells
Schönbeck et al., J Biol Chem 1997
:
We report here that stimulation of human vascular SMC and endothelial cells ( EC ) through CD40 ligand, a mediator recently localized in human atheroma, induced elaboration of the
IL-1beta precursor as well as
activation of cell associated
ICE
Lundqvist et al., Eur J Immunol 1997
(Psoriasis) :
It is concluded that psoriatic scales contain biologically active
IL-1 beta , which has been processed by a mechanism which may be similar to that present in non inflamed plantar stratum corneum, and which does not
involve IL-1 beta converting enzyme
Yao et al., Brain Res Mol Brain Res 1997
:
That dexamethasone inhibited the expression of ICE, suggests that corticosteroids
regulate the secretion of
IL-1beta by microglial cells, in part, by regulating the expression of
ICE
Schumann et al., Blood 1998
:
Taken together, these results show that LPS moderately activates caspase-1 and that
caspase-1 activation
contributes to LPS induction of
IL-1 beta secretion
Johnson et al., Gene 1998
:
However, the pattern of mRNA expression is consistent with a requirement for
caspase-1 mediated
IL-1beta production in chicken immune tissues
Miwa et al., Nat Med 1998
(Fibrosarcoma...) :
This
IL-1beta secretion is
independent of
IL-1beta converting enzyme ( caspase 1 ), yet it is inhibited by caspase inhibitors, indicating that a caspase ( s ) in addition to IL-1beta converting enzyme can process IL-1beta