Oakley et al., J Biol Chem 2009
:
Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta) dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane
Yudoh et al., Int J Rheum Dis 2009
(MAP Kinase Signaling System...) :
Treatment with AGFs inhibited IL-1beta induced overexpression of caveolin-1 in human OA chondrocytes ... Our results suggest that AGFs downregulated IL-1beta induced chondrocyte ageing and overexpression of caveolin-1 in human chondrocytes, which is mediated by kinase cascades involving the p42/44 MAP kinase and PI3-K/Akt signalling pathways