Gene interactions and pathways from curated databases and text-mining

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IL1B — IL4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Pousset et al., Glia 1999 : Interleukin-4 and interleukin-10 regulate IL1-beta induced mouse primary astrocyte activation : a comparative study ... The delayed time dependent effect of IL-4 might be partially explained by the induction of IL-4 receptor alpha-chain mRNA expression by IL-1beta
Ledeboer et al., Glia 2000 : LPS induced levels of IL-1beta were suppressed by IL-10, but not by IL-4 and TGF-beta1/beta2
Hiromatsu et al., J Clin Endocrinol Metab 2000 (Graves Disease) : IFNgamma, TNFalpha, IL-1beta , and IL-6 messenger RNA ( mRNA ) were mainly detected in EM tissue, whereas IL-4 and IL-10 mRNA were detected in only one patient
Harris et al., Prostate 2000 (Disease Models, Animal...) : After 4 weeks of treatment with E ( 2 ) + DHT, a significant increase in transcript levels of IL-4 , IL-5, IL-6, MIP-2, eotaxin, and iNOS was detected , while IL-1beta and TNF-alpha transcript levels only increased slightly
Newton et al., Infect Immun 2000 (Legionnaires' Disease) : Induction of interleukin-4 (IL-4) by legionella pneumophila infection in BALB/c mice and regulation of tumor necrosis factor alpha, IL-6, and IL-1beta
Tsai et al., Life Sci 2000 : Production of tumor necrosis factor (TNF)-alpha and IL-1beta by mouse mesangial cells was not blocked by SSA but production of IL-4 by these cells was inhibited by it ( > 0.1 mM )
Sobel et al., Diabetologia 2000 (Diabetes Mellitus, Type 1) : Cyclophosphamide treatment decreased IL-12, IL-1beta , IL-2, IFN-gamma and TNF-alpha gene expressions in mononuclear spleen cells but IL-4 gene expression increased
Amjad et al., Ir J Med Sci 2001 (Helicobacter Infections) : Inhibitory effect of IL-4 on the production of IL-1 beta and TNF-alpha by gastric mononuclear cells of Helicobacter pylori infected patients ... IL-4 markedly reduced the production of IL-1 beta and tumour necrosis factor-a ( TNF-alpha ) by the gastric mononuclear cells of H. pylori infected patients ( P < 0.01 )
Lottaz et al., J Invest Dermatol 2001 : In interleukin-1beta transfected human dermal fibroblasts, interleukin-8 was induced through an autocrine activity of interleukin-1beta
Goletti et al., Cytokine 2002 : IL-4 inhibited the secretion of IL-1beta and strongly increased that of IL-1ra ; however, these effects were not responsible of IL-4 mediated inhibition of PMA induced HIV expression since anti-IL-1ra antibodies did not revert IL-4 mediated suppression
He et al., J Rheumatol 2002 (Osteoarthritis) : The antiinflammatory cytokine IL-4 blocked LTB4 dependent stimulation of IL-1beta and TNF-alpha synthesis
Bonder et al., Cytokine 2002 : While IL-4 can suppress LPS induced interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta , but not TNFalpha production by the more differentiated cells ... In addition, like monocytes and MDMac, IFNalpha treated monocytes expressed normal levels of the IL-4 receptor alpha chain and IL-4 significantly suppressed LPS induced IL-1 beta production
Bonder et al., J Interferon Cytokine Res 2002 : A second mechanism, apparent some 48 h after exposure to IFN-gamma, involved a significant suppression of IL-4 receptor (IL-4R) expression at the cell surface, and this correlated with the loss of additional functional responses to IL-4, including IL-4 induced suppression of LPS induced IL-1beta production
Wirjatijasa et al., J Neurosci Res 2002 : The LPS induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM, whereas IL-4 or IL-10 did not inhibit IL-1beta- or TNF-alpha secretion
Augstein et al., Biochem Biophys Res Commun 2003 (Diabetes Mellitus, Type 1) : To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice, we analysed the IL-1beta induced ICAM-1 expression on islet-cells and the LFA-1, CD25, IL-2, IFN-gamma, IL-4 , and IL-10 expression on splenocytes
Hassanain et al., Neuroscience 2003 : In particular, interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of interleukin-1beta on this form of emotional behavior are mediated via a 5-HT2 receptor mechanism
Coëffier et al., Clin Nutr 2003 (Inflammatory Bowel Diseases) : IL-1beta stimulation increased IL-6 and IL-8, but did not affect IL-4 and IL-10 production
Fenton et al., J Immunol 1992 : We have previously shown that IL-4 reduces steady state messenger RNA ( mRNA ) levels for IL-1 beta in human monocytes by decreasing both IL-1 beta transcription and the t1/2 of newly formed IL-1 beta mRNA transcripts ... Furthermore, although IL-4 suppressed expression of both IL-1 beta and IL-6, it up-regulated synthesis of IL-1ra mRNA and protein
Fujiwara et al., Cancer Res 1992 : Specific inhibition of interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory role of interleukin 1 in the generation of lymphokine activated killer cells
Babina et al., J Leukoc Biol 2004 (Inflammation) : Of note, MC precultured in the presence of IL-4 [ alone or plus stem cell factor (SCF) ] before anti-IgE stimulation, acquired the ability to produce IL-5, and IL-1beta was concomitantly suppressed
Herbert et al., FEBS Lett 1992 : IL-4 inhibits LPS-, IL-1 beta- and TNF alpha induced expression of tissue factor in endothelial cells and monocytes
Walker et al., J Immunol 1992 (Mycobacterium Infections) : In particular, IL-1 (-alpha and -beta) , IL-2, TNF (-alpha and -beta), and IFN-gamma mRNA were readily detected , whereas IL-3, IL-4 , IL-5, IL-6, IL-7, and granulocyte-macrophage colony stimulating factor mRNA were not detected, or were detectable only at very low levels
Zhao et al., Cytokine 2004 : Following unilateral cochlear ablation, there is decreased expression of IL-4 and IL-10 in me/me brains compared to wild-type, but IL-1beta is significantly increased
Briolay et al., J Clin Immunol 1992 (Arthritis, Rheumatoid) : IL-4 inhibited the production of IL-6, IL-1 beta , and tumor necrosis factor alpha (TNF alpha) by both controls and rheumatoid patients
Eslick et al., Inflammation 2004 : In contrast, IL-4 and IL-10 inhibit LPS or IL-1beta induced pro-inflammatory cytokine production
Luz et al., Neuropeptides 2006 (Dehydration...) : These results suggest that the central activation of interleukin-1 receptors by IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Lyons et al., J Neurochem 2007 (Encephalitis) : We also report that Abeta induced increases in expression of MHCII and IL-1beta were similarly attenuated by IL-4 and minocycline in glial cultures prepared from neonatal rats
Cao et al., J Neurochem 2007 (Encephalitis...) : Induction of interleukin-1beta by interleukin-4 in lipopolysaccharide treated mixed glial cultures : microglial dependent effects ... Interestingly, IL-4 significantly enhanced IL-1beta secretion and did not affect monocyte chemoattractant protein-1 release, even though IL-4 considerably inhibited IL-6, tumor necrosis factor alpha, and nitric oxide production from rat neonatal mixed glia ... Further, IL-4 exhibited inhibitory effects on IL-1beta production in microglial enriched cultures, while significantly increasing IL-1beta production in microglial depleted glia ... The enhancing effect of IL-4 on IL-1beta production was found to be inversely correlated with the percentage of microglia present in the mixed glial population
Sokolovska et al., Vaccine 2007 : Inhibition of IL-1beta and IL-18 secretion by DCs via inhibition of caspase-1 also led to a marked decrease of IL-4 and IL-5 by CD4 ( + ) T cells
Hirota et al., J Exp Med 2007 (Arthritis, Experimental...) : The CCL20 production by synoviocytes is augmented in vitro by IL-1beta , IL-17, or tumor necrosis factor alpha, and is suppressed by IFN-gamma or IL-4
Bernardino et al., J Neurochem 2008 (Encephalitis...) : Potentiation of AMPA toxicity was prevented when IL-1beta production or its receptor signaling were blocked by an inhibitor of interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Rachakonda et al., Arthritis Rheum 2008 (Disease Models, Animal...) : Using articular chondrocytes, we showed that our COX-2 promoter construct expressed IL-4 only in the presence of IL-1beta and TNFalpha ... IL-4 expressed in the presence of IL-1beta and TNFalpha down-regulated a series of inflammation mediators, prostaglandins, and matrix metalloproteinases
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Puliti et al., Microbes Infect 2010 (Arthritis, Infectious...) : Amelioration of arthritis in B7-1 deficient mice was accompanied by a lower local production of IL-1 beta and IL-18, and increase in IL-4 and IL-10 secretion
Hart et al., Immunology 1991 : To investigate whether opposing activities of IL-4 reflect a difference in the target cell studied, due either to cell maturation or the site from which the cells were isolated, we examined the effect of IL-4 on human peritoneal macrophage production of IL-1 beta , TNF-alpha and prostaglandin E2 ( PGE2 )
Hart et al., Lymphokine Res 1990 : IL-4 can also suppress the increased release of IL-1 beta and TNF alpha by monocytes incubated with indomethacin, a non-steroidal anti-inflammatory drug
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Donnelly et al., J Immunol 1990 : Northern dot blot analyses revealed that IL-4 not only dramatically reduced the steady-state IL-1 beta mRNA levels in LPS stimulated monocytes, but also those of TNF-alpha and IL-6
te Velde et al., Blood 1990 : Interleukin-4 (IL-4) inhibits secretion of IL-1 beta , tumor necrosis factor alpha, and IL-6 by human monocytes ... To elucidate which cytokines produced by monocytes are controlled by IL-4, we tested the effect of IL-4 on the secretion of IL-1 alpha, IL-1 beta , TNF alpha, and IL-6 induced by LPS or IFN gamma ... IL-4 was found to inhibit the secretion of IL-1 beta and TNF alpha by activated monocytes almost 100 % ... The reduced secretion of IL-1 beta and TNF alpha was specifically induced by IL-4 because anti-IL-4 antiserum completely restored normal monokine production
Gauchat et al., Eur Cytokine Netw 1990 (Hypersensitivity, Immediate) : Cytokine gene expression in atopics : effect of IL-4 on IL-1 beta and IL-6 mRNA levels ... In the presence of IL-4 steady state levels of IL-1 beta and IL-6 mRNA were decreased even if cells were co-stimulated with polyclonal activators such as PMA, PWM or PHA
Rodriguez-Cimadevilla et al., Blood 1990 (Leukemia, Myeloid, Acute) : Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia : role of interleukin-1 as an endogenous inducer
Essner et al., J Immunol 1989 : RNA hybridization studies demonstrated that IL-4 suppressed the expression of IL-1 alpha, IL-1 beta , and TNF mRNA
Mauviel et al., Biochem Biophys Res Commun 1988 : The ability of the two forms of interleukin-1 , IL-1 alpha and IL-1 beta, to induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Ferrajoli et al., Ann Hematol 1993 : When tested by enzyme linked immunosorbent assay ( ELISA ), IL-4 suppressed cellular IL-1 beta production, and, similar to IL-4, anti-IL-1 beta neutralizing antibodies inhibited CFU-GM colony growth, suggesting that the inhibition of endogenous IL-1 beta is a factor in regulating the IL-4 effect
Hart et al., J Leukoc Biol 1995 : Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ), diminished IL-1 beta production in response to both IL-4 and IL-10, and compared with fresh monocytes ( 3 ), diminished CD14 expression in response to IL-4, and ( 4 ) a lesser increase in CD23 expression in response to IL-4
Sandborg et al., J Immunol 1995 : IL-4 expression in human T cells is selectively inhibited by IL-1 alpha and IL-1 beta ... IL-1 alpha and IL-1 beta inhibited IL-4 production by 20 to 80 % in > 92 % of healthy individuals ( p = 0.0001, paired t-test )
Sandler et al., Cytokine 1995 : The medium nitrite accumulation, as an index of nitric oxide formation, was not influenced by IL-4 ( 10 ng/ml ) alone, whilst IL-1 beta stimulation of medium nitrite was partly reduced by IL-4
Hart et al., Immunology 1995 (Arthritis) : IL-10 and IL-4 suppressed equally IL-1 beta production by the same cells
Yano et al., J Leukoc Biol 1995 : IL-4 , IL-10, and IL-13 suppressed the generation of antitumor activity and cytokine production ( IL-1 beta and TNF-alpha ) of monocytes stimulated with MCAF plus norMDP or LPS
Dazzi et al., Clin Immunol Immunopathol 1995 (Leukemia, Lymphocytic, Chronic, B-Cell) : The effect of IL-4 is not mediated by quantitative modifications of class II and B7 molecule expression or of IL-1 beta production
Zhou et al., J Leukoc Biol 1994 (Inflammation) : Interleukin-4 , when added together with bacterial lipopolysaccharide (LPS), suppressed LPS induced increases in mRNA levels of IL-1 alpha, IL-1 beta , IL-8, and TNF-alpha in alveolar macrophages ... Interleukin-1 beta expression was completely inhibited by IL-4
Malyak et al., J Clin Immunol 1994 : IL-4 enhanced LPS induced IL-1ra production by PMN and inhibited LPS induced IL-1 beta production
Jenkins et al., Cytokine 1993 : However, our data confirmed that IL-4 up-regulated LPS induced IL-1ra and down-regulated LPS induced IL-1 beta
Huether et al., Gene 1993 : Porcine IL-1 beta is down-regulated by dexamethasone, polymyxin B, and IL-4 in a fashion kinetically similar to the other reported species
Sillaber et al., Exp Hematol 1993 (Leukemia, Mast-Cell) : The effect of IL-4 on IL-1 beta gene product expression was time- and dose dependent ( maximum effects obtained with 100 U/mL of rhIL-4 ) ... Furthermore, our study provides evidence that IL-4 regulates IL-1 beta gene product expression in HMC-1 cells
Dechanet et al., J Immunol 1993 (Arthritis, Rheumatoid) : Herein, we show that IL-4 strongly inhibited PDGF and IL-1 beta stimulated rheumatoid arthritis synoviocyte proliferation in a dose dependent manner and through its 130 kDa receptor
Bendrups et al., Rheumatol Int 1993 (Arthritis, Rheumatoid...) : The effects of recombinant human interleukin-4 (IL-4) and the glucocorticoid, dexamethasone, on tumor necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) levels in cultures of rheumatoid and osteoarthritic synovial tissue were studied
Sugiyama et al., J Rheumatol 1995 (Arthritis, Rheumatoid) : IL-4 alone inhibited the production of IL-1 beta , IL-6, and IL-8 by 32, 35, and 50 %, respectively
Méndez-Samperio et al., Clin Exp Immunol 1996 : The effect of IL-4 on the secretion of IL-1 beta was specific, since a complete reversion was obtained with a neutralizing MoAb to human IL-4 ... Interestingly, the induction of IL-1 beta was regulated by IL-4 , at least in part, by direct mechanism mediated through the extracellular domain of the 130-kD IL-4 receptor, as demonstrated by incubation of the mononuclear cells with the neutralizing anti-IL-4 receptor MoAb
Yoza et al., J Biol Chem 1996 : In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene
Joyce et al., J Interferon Cytokine Res 1996 : IL-4 , IL-10, TGF-beta, and glucocorticoids ( GC ) all suppress the lipopolysaccharide (LPS) stimulated release of TNF-alpha and IL-1beta but vary in their effects on IL-1RA and sTNF-R
Sébire et al., Cytokine 1996 : The effect of interleukin 4 (IL-4) and IL-13 on IL-6 and IL-1 beta production by human embryonic microglial cells and human peripheral blood monocyte cells ( PBMC ) was compared ... IL-4 and IL-13 increased also IL-1 beta production by human microglial cells
West et al., Gastroenterology 1996 (Colitis, Ulcerative...) : IL-4 levels were measured by enzyme linked immunosorbent assay in cultures of control and inflammatory bowel disease LPMCs, and the effect of IL-4 on LPMC proliferation and interaction with IL-2, IL-1 beta , lipopolysaccharide, bacterial antigens, superantigen, and antibodies to various T-cell receptors was investigated
Yamaoka et al., Scand J Gastroenterol 1995 (Gastritis...) : Although IL-1 beta and IFN-gamma mRNA were detected in most specimens, IL-2, IL-3, IL-4 , IL-5, IL-9, TNF-alpha, and IFN-beta mRNA were not detected at all
Kang et al., Spine (Phila Pa 1976) 1997 (Intervertebral Disc Displacement) : Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta
Kiriyama et al., J Neuroimmunol 1997 (Glioblastoma) : In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP
Méndez-Samperio et al., Clin Diagn Lab Immunol 1997 (Arthritis, Rheumatoid) : Interleukin-4 inhibits secretion of interleukin-1beta in the response of human cells to mycobacterial heat shock proteins ... In this study, we found that IL-4 significantly suppressed IL-1beta secretion induced by BCG and the 70- and 65-kDa HSP
Berghella et al., Cancer Immunol Immunother 1998 (Colorectal Neoplasms) : To address these questions at the immunological level in a group of patients and healthy subjects, we determined the sIL-2R level in the serum and its release from peripheral blood mononuclear cells ( PBMC ) as a function of tumour necrosis factor (TNF) alpha, IL-1 alpha, IL-1 beta , IL-2, interferon (IFN) gamma, IL-4, IL-6 and IL-10 levels in the serum and PBMC production ; and PBMC proliferative responses to IL-2, IL-4 and anti-CD3 monoclonal antibody ( CD3 ), variously combined
van der Velden et al., Cytokine 1998 (Second Messenger Systems) : IL-1 beta , and to a lesser extent, TNF-alpha and IL-4 increased NEP activity and expression, whereas IFN-gamma decreased NEP
Bonder et al., J Immunol 1998 : In contrast, IL-4 consistently down-regulated IL-1beta production by cultured monocytes ... Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that IL-4 can suppress IL-1beta but not TNF-alpha production by LPS stimulated monocytes in the presence of little or no functioning gammac ... IL-4 also suppressed IL-1beta but not TNF-alpha production by Mono Mac 6 cells, which express minimal levels of gammac
Bishop-Bailey et al., Biochem Biophys Res Commun 1998 : Furthermore, IL-1 beta inhibited IL-4 induced VCAM-1 expression, which was also reversed by COX-2 inhibition
Aihara et al., Dig Dis Sci 1998 : Live H. pylori induced production of many cytokines, such as IL-1beta , IL-10, IL-8, IFN-gamma, and TNF-alpha, whereas we could not detect IL-2 or IL-4
Goodwin et al., Am J Reprod Immunol 1998 : Both IL-10 and IL-4 inhibited IL-1 beta- and TNF-alpha induced PGE2 production but had no significant effects on the production of PGE2 under basal conditions