◀ Back to IL1B
IL1B — IL4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12-mediated signaling events:
IL1 beta (IL1B)
→
IL4 (IL4)
(modification, activates)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
Text-mined interactions from Literome
Pousset et al., Glia 1999
:
Interleukin-4 and interleukin-10
regulate IL1-beta induced mouse primary astrocyte activation : a comparative study ... The delayed time dependent effect of IL-4 might be partially explained by the
induction of
IL-4 receptor alpha-chain mRNA expression by
IL-1beta
Ledeboer et al., Glia 2000
:
LPS induced levels of
IL-1beta were
suppressed by IL-10, but not by
IL-4 and TGF-beta1/beta2
Hiromatsu et al., J Clin Endocrinol Metab 2000
(Graves Disease) :
IFNgamma, TNFalpha,
IL-1beta , and IL-6 messenger RNA ( mRNA ) were mainly
detected in EM tissue, whereas
IL-4 and IL-10 mRNA were detected in only one patient
Harris et al., Prostate 2000
(Disease Models, Animal...) :
After 4 weeks of treatment with E ( 2 ) + DHT, a significant increase in transcript levels of
IL-4 , IL-5, IL-6, MIP-2, eotaxin, and iNOS was
detected , while
IL-1beta and TNF-alpha transcript levels only increased slightly
Newton et al., Infect Immun 2000
(Legionnaires' Disease) :
Induction of
interleukin-4 (IL-4) by legionella pneumophila infection in BALB/c mice and regulation of tumor necrosis factor alpha, IL-6, and
IL-1beta
Tsai et al., Life Sci 2000
:
Production of tumor necrosis factor (TNF)-alpha and
IL-1beta by mouse mesangial cells was not blocked by SSA but production of
IL-4 by these cells was
inhibited by it ( > 0.1 mM )
Sobel et al., Diabetologia 2000
(Diabetes Mellitus, Type 1) :
Cyclophosphamide treatment decreased IL-12,
IL-1beta , IL-2, IFN-gamma and TNF-alpha gene expressions in mononuclear spleen cells but
IL-4 gene expression
increased
Amjad et al., Ir J Med Sci 2001
(Helicobacter Infections) :
Inhibitory
effect of
IL-4 on the production of
IL-1 beta and TNF-alpha by gastric mononuclear cells of Helicobacter pylori infected patients ...
IL-4 markedly
reduced the production of
IL-1 beta and tumour necrosis factor-a ( TNF-alpha ) by the gastric mononuclear cells of H. pylori infected patients ( P < 0.01 )
Lottaz et al., J Invest Dermatol 2001
:
In interleukin-1beta transfected human dermal fibroblasts,
interleukin-8 was
induced through an autocrine activity of
interleukin-1beta
Goletti et al., Cytokine 2002
:
IL-4 inhibited the secretion of
IL-1beta and strongly increased that of IL-1ra ; however, these effects were not responsible of IL-4 mediated inhibition of PMA induced HIV expression since anti-IL-1ra antibodies did not revert IL-4 mediated suppression
He et al., J Rheumatol 2002
(Osteoarthritis) :
The antiinflammatory cytokine
IL-4 blocked LTB4 dependent stimulation of
IL-1beta and TNF-alpha synthesis
Bonder et al., Cytokine 2002
:
While IL-4 can suppress LPS induced interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes,
IL-4 can
suppress LPS induced
IL-1 beta , but not TNFalpha production by the more differentiated cells ... In addition, like monocytes and MDMac, IFNalpha treated monocytes expressed normal levels of the IL-4 receptor alpha chain and
IL-4 significantly
suppressed LPS induced
IL-1 beta production
Bonder et al., J Interferon Cytokine Res 2002
:
A second mechanism, apparent some 48 h after exposure to IFN-gamma, involved a significant suppression of IL-4 receptor (IL-4R) expression at the cell surface, and this correlated with the loss of additional functional responses to IL-4, including
IL-4 induced suppression of LPS induced
IL-1beta production
Wirjatijasa et al., J Neurosci Res 2002
:
The LPS induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM, whereas
IL-4 or IL-10 did not
inhibit IL-1beta- or TNF-alpha secretion
Augstein et al., Biochem Biophys Res Commun 2003
(Diabetes Mellitus, Type 1) :
To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice, we analysed the
IL-1beta induced ICAM-1 expression on islet-cells and the LFA-1, CD25, IL-2, IFN-gamma,
IL-4 , and IL-10 expression on splenocytes
Hassanain et al., Neuroscience 2003
:
In particular,
interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of
interleukin-1beta on this form of emotional behavior are
mediated via a 5-HT2 receptor mechanism
Coëffier et al., Clin Nutr 2003
(Inflammatory Bowel Diseases) :
IL-1beta stimulation increased IL-6 and IL-8, but did not
affect IL-4 and IL-10 production
Fenton et al., J Immunol 1992
:
We have previously shown that
IL-4 reduces steady state messenger RNA ( mRNA ) levels for
IL-1 beta in human monocytes by decreasing both IL-1 beta transcription and the t1/2 of newly formed IL-1 beta mRNA transcripts ... Furthermore, although
IL-4 suppressed expression of both
IL-1 beta and IL-6, it up-regulated synthesis of IL-1ra mRNA and protein
Fujiwara et al., Cancer Res 1992
:
Specific inhibition of
interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory
role of
interleukin 1 in the generation of lymphokine activated killer cells
Babina et al., J Leukoc Biol 2004
(Inflammation) :
Of note, MC precultured in the
presence of
IL-4 [ alone or plus stem cell factor (SCF) ] before anti-IgE stimulation, acquired the ability to produce IL-5, and
IL-1beta was concomitantly suppressed
Herbert et al., FEBS Lett 1992
:
IL-4 inhibits LPS-,
IL-1 beta- and TNF alpha induced expression of tissue factor in endothelial cells and monocytes
Walker et al., J Immunol 1992
(Mycobacterium Infections) :
In particular,
IL-1 (-alpha and -beta) , IL-2, TNF (-alpha and -beta), and IFN-gamma mRNA were readily
detected , whereas IL-3,
IL-4 , IL-5, IL-6, IL-7, and granulocyte-macrophage colony stimulating factor mRNA were not detected, or were detectable only at very low levels
Zhao et al., Cytokine 2004
:
Following unilateral cochlear ablation, there is decreased expression of
IL-4 and IL-10 in me/me brains compared to wild-type, but
IL-1beta is significantly
increased
Briolay et al., J Clin Immunol 1992
(Arthritis, Rheumatoid) :
IL-4 inhibited the production of IL-6,
IL-1 beta , and tumor necrosis factor alpha (TNF alpha) by both controls and rheumatoid patients
Eslick et al., Inflammation 2004
:
In contrast,
IL-4 and IL-10
inhibit LPS or
IL-1beta induced pro-inflammatory cytokine production
Luz et al., Neuropeptides 2006
(Dehydration...) :
These results suggest that the central
activation of
interleukin-1 receptors by
IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Lyons et al., J Neurochem 2007
(Encephalitis) :
We also report that Abeta induced increases in expression of MHCII and
IL-1beta were similarly
attenuated by
IL-4 and minocycline in glial cultures prepared from neonatal rats
Cao et al., J Neurochem 2007
(Encephalitis...) :
Induction of
interleukin-1beta by
interleukin-4 in lipopolysaccharide treated mixed glial cultures : microglial dependent effects ... Interestingly,
IL-4 significantly
enhanced IL-1beta secretion and did not affect monocyte chemoattractant protein-1 release, even though IL-4 considerably inhibited IL-6, tumor necrosis factor alpha, and nitric oxide production from rat neonatal mixed glia ... Further,
IL-4 exhibited inhibitory
effects on
IL-1beta production in microglial enriched cultures, while significantly increasing IL-1beta production in microglial depleted glia ... The enhancing
effect of
IL-4 on
IL-1beta production was found to be inversely correlated with the percentage of microglia present in the mixed glial population
Sokolovska et al., Vaccine 2007
:
Inhibition of
IL-1beta and IL-18 secretion by DCs via inhibition of caspase-1 also
led to a marked decrease of
IL-4 and IL-5 by CD4 ( + ) T cells
Hirota et al., J Exp Med 2007
(Arthritis, Experimental...) :
The CCL20 production by synoviocytes is augmented in vitro by
IL-1beta , IL-17, or tumor necrosis factor alpha, and is
suppressed by IFN-gamma or
IL-4
Bernardino et al., J Neurochem 2008
(Encephalitis...) :
Potentiation of AMPA toxicity was prevented when
IL-1beta production or its receptor signaling were
blocked by an inhibitor of
interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Rachakonda et al., Arthritis Rheum 2008
(Disease Models, Animal...) :
Using articular chondrocytes, we showed that our COX-2 promoter construct expressed
IL-4 only in the
presence of
IL-1beta and TNFalpha ...
IL-4 expressed in the
presence of
IL-1beta and TNFalpha down-regulated a series of inflammation mediators, prostaglandins, and matrix metalloproteinases
Haber et al., Exp Parasitol 2009
(Hyperalgesia...) :
Leishmania major
: interleukin-13 increases the infection induced hyperalgesia and the levels of
interleukin-1beta and interleukin-12 in rats
Puliti et al., Microbes Infect 2010
(Arthritis, Infectious...) :
Amelioration of arthritis in B7-1 deficient mice was accompanied by a lower local production of
IL-1 beta and IL-18, and
increase in
IL-4 and IL-10 secretion
Hart et al., Immunology 1991
:
To investigate whether opposing activities of IL-4 reflect a difference in the target cell studied, due either to cell maturation or the site from which the cells were isolated, we examined the
effect of
IL-4 on human peritoneal macrophage production of
IL-1 beta , TNF-alpha and prostaglandin E2 ( PGE2 )
Hart et al., Lymphokine Res 1990
:
IL-4 can also
suppress the increased release of
IL-1 beta and TNF alpha by monocytes incubated with indomethacin, a non-steroidal anti-inflammatory drug
Elias et al., Chest 1990
(Pneumonia...) :
To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the
effects of recombinant
interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production,
interleukin-1-beta production, and interleukin-6 production
Donnelly et al., J Immunol 1990
:
Northern dot blot analyses revealed that
IL-4 not only dramatically
reduced the steady-state
IL-1 beta mRNA levels in LPS stimulated monocytes, but also those of TNF-alpha and IL-6
te Velde et al., Blood 1990
:
Interleukin-4 (IL-4) inhibits secretion of
IL-1 beta , tumor necrosis factor alpha, and IL-6 by human monocytes ... To elucidate which cytokines produced by monocytes are controlled by IL-4, we tested the
effect of
IL-4 on the secretion of IL-1 alpha,
IL-1 beta , TNF alpha, and IL-6 induced by LPS or IFN gamma ...
IL-4 was found to
inhibit the secretion of
IL-1 beta and TNF alpha by activated monocytes almost 100 % ... The reduced secretion of
IL-1 beta and TNF alpha was specifically
induced by
IL-4 because anti-IL-4 antiserum completely restored normal monokine production
Gauchat et al., Eur Cytokine Netw 1990
(Hypersensitivity, Immediate) :
Cytokine gene expression in atopics :
effect of
IL-4 on
IL-1 beta and IL-6 mRNA levels ... In the
presence of
IL-4 steady state levels of
IL-1 beta and IL-6 mRNA were decreased even if cells were co-stimulated with polyclonal activators such as PMA, PWM or PHA
Rodriguez-Cimadevilla et al., Blood 1990
(Leukemia, Myeloid, Acute) :
Coordinate secretion of
interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia :
role of
interleukin-1 as an endogenous inducer
Essner et al., J Immunol 1989
:
RNA hybridization studies demonstrated that
IL-4 suppressed the expression of IL-1 alpha,
IL-1 beta , and TNF mRNA
Mauviel et al., Biochem Biophys Res Commun 1988
:
The ability of the two forms of
interleukin-1 , IL-1 alpha and IL-1 beta, to
induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Ferrajoli et al., Ann Hematol 1993
:
When tested by enzyme linked immunosorbent assay ( ELISA ),
IL-4 suppressed cellular
IL-1 beta production, and, similar to IL-4, anti-IL-1 beta neutralizing antibodies inhibited CFU-GM colony growth, suggesting that the inhibition of endogenous IL-1 beta is a factor in regulating the IL-4 effect
Hart et al., J Leukoc Biol 1995
:
Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ), diminished
IL-1 beta production in
response to both
IL-4 and IL-10, and compared with fresh monocytes ( 3 ), diminished CD14 expression in response to IL-4, and ( 4 ) a lesser increase in CD23 expression in response to IL-4
Sandborg et al., J Immunol 1995
:
IL-4 expression in human T cells is selectively
inhibited by IL-1 alpha and
IL-1 beta ... IL-1 alpha and
IL-1 beta inhibited
IL-4 production by 20 to 80 % in > 92 % of healthy individuals ( p = 0.0001, paired t-test )
Sandler et al., Cytokine 1995
:
The medium nitrite accumulation, as an index of nitric oxide formation, was not influenced by IL-4 ( 10 ng/ml ) alone, whilst
IL-1 beta stimulation of medium nitrite was partly
reduced by
IL-4
Hart et al., Immunology 1995
(Arthritis) :
IL-10 and
IL-4 suppressed equally
IL-1 beta production by the same cells
Yano et al., J Leukoc Biol 1995
:
IL-4 , IL-10, and IL-13
suppressed the generation of antitumor activity and cytokine production (
IL-1 beta and TNF-alpha ) of monocytes stimulated with MCAF plus norMDP or LPS
Dazzi et al., Clin Immunol Immunopathol 1995
(Leukemia, Lymphocytic, Chronic, B-Cell) :
The effect of
IL-4 is not
mediated by quantitative modifications of class II and B7 molecule expression or of
IL-1 beta production
Zhou et al., J Leukoc Biol 1994
(Inflammation) :
Interleukin-4 , when added together with bacterial lipopolysaccharide (LPS),
suppressed LPS induced increases in mRNA levels of IL-1 alpha,
IL-1 beta , IL-8, and TNF-alpha in alveolar macrophages ...
Interleukin-1 beta expression was completely
inhibited by
IL-4
Malyak et al., J Clin Immunol 1994
:
IL-4 enhanced LPS induced IL-1ra production by PMN and
inhibited LPS induced
IL-1 beta production
Jenkins et al., Cytokine 1993
:
However, our data confirmed that
IL-4 up-regulated LPS induced IL-1ra and
down-regulated LPS induced
IL-1 beta
Huether et al., Gene 1993
:
Porcine
IL-1 beta is
down-regulated by dexamethasone, polymyxin B, and
IL-4 in a fashion kinetically similar to the other reported species
Sillaber et al., Exp Hematol 1993
(Leukemia, Mast-Cell) :
The
effect of
IL-4 on
IL-1 beta gene product expression was time- and dose dependent ( maximum effects obtained with 100 U/mL of rhIL-4 ) ... Furthermore, our study provides evidence that
IL-4 regulates
IL-1 beta gene product expression in HMC-1 cells
Dechanet et al., J Immunol 1993
(Arthritis, Rheumatoid) :
Herein, we show that
IL-4 strongly
inhibited PDGF and
IL-1 beta stimulated rheumatoid arthritis synoviocyte proliferation in a dose dependent manner and through its 130 kDa receptor
Bendrups et al., Rheumatol Int 1993
(Arthritis, Rheumatoid...) :
The
effects of recombinant human
interleukin-4 (IL-4) and the glucocorticoid, dexamethasone, on tumor necrosis factor alpha (TNF alpha) and
interleukin-1 beta (IL-1 beta) levels in cultures of rheumatoid and osteoarthritic synovial tissue were studied
Sugiyama et al., J Rheumatol 1995
(Arthritis, Rheumatoid) :
IL-4 alone
inhibited the production of
IL-1 beta , IL-6, and IL-8 by 32, 35, and 50 %, respectively
Méndez-Samperio et al., Clin Exp Immunol 1996
:
The
effect of
IL-4 on the secretion of
IL-1 beta was specific, since a complete reversion was obtained with a neutralizing MoAb to human IL-4 ... Interestingly, the induction of
IL-1 beta was
regulated by
IL-4 , at least in part, by direct mechanism mediated through the extracellular domain of the 130-kD IL-4 receptor, as demonstrated by incubation of the mononuclear cells with the neutralizing anti-IL-4 receptor MoAb
Yoza et al., J Biol Chem 1996
:
In human monocytes,
interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a
result of increased transcription of the
interleukin 1beta gene
Joyce et al., J Interferon Cytokine Res 1996
:
IL-4 , IL-10, TGF-beta, and glucocorticoids ( GC ) all
suppress the lipopolysaccharide (LPS) stimulated release of TNF-alpha and
IL-1beta but vary in their effects on IL-1RA and sTNF-R
Sébire et al., Cytokine 1996
:
The
effect of
interleukin 4 (IL-4) and IL-13 on IL-6 and
IL-1 beta production by human embryonic microglial cells and human peripheral blood monocyte cells ( PBMC ) was compared ...
IL-4 and IL-13
increased also
IL-1 beta production by human microglial cells
West et al., Gastroenterology 1996
(Colitis, Ulcerative...) :
IL-4 levels were measured by enzyme linked immunosorbent assay in cultures of control and inflammatory bowel disease LPMCs, and the
effect of
IL-4 on LPMC proliferation and interaction with IL-2,
IL-1 beta , lipopolysaccharide, bacterial antigens, superantigen, and antibodies to various T-cell receptors was investigated
Yamaoka et al., Scand J Gastroenterol 1995
(Gastritis...) :
Although
IL-1 beta and IFN-gamma mRNA were detected in most specimens, IL-2, IL-3,
IL-4 , IL-5, IL-9, TNF-alpha, and IFN-beta mRNA were not
detected at all
Kang et al., Spine (Phila Pa 1976) 1997
(Intervertebral Disc Displacement) :
Normal and herniated human intervertebral disc specimens were cultured to study the
effects of
interleukin-1 beta on the production of nitric oxide,
interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide,
interleukin-6 , and prostaglandin E2 in
response to
interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide,
interleukin-6 , and prostaglandin E2 in
response to
interleukin-1 beta
Kiriyama et al., J Neuroimmunol 1997
(Glioblastoma) :
In human glioblastoma A172 cells,
interleukin-6 (IL-6) production was
induced by
interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP
Méndez-Samperio et al., Clin Diagn Lab Immunol 1997
(Arthritis, Rheumatoid) :
Interleukin-4 inhibits secretion of
interleukin-1beta in the response of human cells to mycobacterial heat shock proteins ... In this study, we found that
IL-4 significantly
suppressed IL-1beta secretion induced by BCG and the 70- and 65-kDa HSP
Berghella et al., Cancer Immunol Immunother 1998
(Colorectal Neoplasms) :
To address these questions at the immunological level in a group of patients and healthy subjects, we determined the sIL-2R level in the serum and its release from peripheral blood mononuclear cells ( PBMC ) as a function of tumour necrosis factor (TNF) alpha, IL-1 alpha,
IL-1 beta , IL-2, interferon (IFN) gamma, IL-4, IL-6 and IL-10 levels in the serum and PBMC production ; and PBMC proliferative
responses to IL-2,
IL-4 and anti-CD3 monoclonal antibody ( CD3 ), variously combined
van der Velden et al., Cytokine 1998
(Second Messenger Systems) :
IL-1 beta , and to a lesser extent, TNF-alpha and
IL-4 increased NEP activity and expression, whereas IFN-gamma decreased NEP
Bonder et al., J Immunol 1998
:
In contrast,
IL-4 consistently
down-regulated IL-1beta production by cultured monocytes ... Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that
IL-4 can
suppress IL-1beta but not TNF-alpha production by LPS stimulated monocytes in the presence of little or no functioning gammac ...
IL-4 also
suppressed IL-1beta but not TNF-alpha production by Mono Mac 6 cells, which express minimal levels of gammac
Bishop-Bailey et al., Biochem Biophys Res Commun 1998
:
Furthermore,
IL-1 beta inhibited
IL-4 induced VCAM-1 expression, which was also reversed by COX-2 inhibition
Aihara et al., Dig Dis Sci 1998
:
Live H. pylori
induced production of many cytokines, such as
IL-1beta , IL-10, IL-8, IFN-gamma, and TNF-alpha, whereas we could not detect IL-2 or
IL-4
Goodwin et al., Am J Reprod Immunol 1998
:
Both IL-10 and
IL-4 inhibited
IL-1 beta- and TNF-alpha induced PGE2 production but had no significant effects on the production of PGE2 under basal conditions