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MYLIP — TLR3

Text-mined interactions from Literome

Dai et al., Blood 2008 : We found that miR-146a , a negative regulator of Toll-like receptor ( TLR ) signaling, was decreased in freshly isolated splenic lymphocytes from estrogen treated mice compared with placebo controls
Sheedy et al., Ann Rheum Dis 2008 (Arthritis, Rheumatoid...) : Both have multiple targets, with miR-146 inhibiting TLR signalling and miR-155 regulating Th1 cells and also, interestingly, positively regulating mRNA for TNFalpha
Liu et al., Proc Natl Acad Sci U S A 2009 (Inflammation) : These data demonstrate a negative-feedback loop in which TLR stimulation induces miR-147 to prevent excessive inflammatory responses
Cho et al., J Cell Physiol 2010 (Calcinosis) : Overexpression of miR-146a induced the inhibition of IRAK1 expression and inhibited basal and TNF-alpha- and TLR ligand induced osteogenic differentiation
Tarassishin et al., Glia 2011 : Astrocyte miR-155/miR155* were induced by cytokines and TLR ligands with a distinct hierarchy and involved in proinflammatory cytokine gene induction by targeting suppressor of cytokine signaling 1, a negative regulator of cytokine signaling and potentially other factors
Koch et al., Proc Natl Acad Sci U S A 2012 : miR-155 is regulated by Toll-like receptor ( TLR ) ligands in monocyte derived cells and has been shown to be induced in macrophages during H. pylori infection
Kopriva et al., PloS one 2013 : We reported that activation of TLR3 produces the PE-like symptoms of hypertension, endothelial dysfunction, and proteinuria in mice only when pregnant, but whether TLR3 activation in pregnant mice and human cytotrophoblasts (CTBs) increases miR-210 and modulates its targets related to inflammation are unknown ... These findings demonstrate that TLR3 activation induces placental miR-210 via HIF-1a and NF-?Bp50 leading to decreased STAT6 and IL-4 levels and this may contribute to the development of PE