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BCR — FOXO1
Text-mined interactions from Literome
Christian et al., J Biol Chem 2003
:
Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway, expressing constitutively active Rap2 ( Rap2V12 ) reduced
BCR induced phosphorylation of Akt and
FKHR
Hinman et al., J Immunol 2007
:
Previously,
BCR induced phosphorylation of
FOXO1 was shown to lead to a block in nuclear localization and subsequent protein degradation ... The protein kinase Cbeta inhibitor Gö6850 had minimal effects on
BCR mediated
FOXO1 mRNA down-regulation