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BMP2 — BMPR2

Pathways - manually collected, often from reviews:

• BioCarta alk in cardiac myocytes: BMPR-II/ALK3 complex (BMPR2-BMPR1A) → BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) (modification, collaborate)
  
• BioCarta alk in cardiac myocytes: BMPR-II/ALK3 complex (BMPR2-BMPR1A) → BMP (BMP7/BMP2/BMP5/BMP10/BMP4) (modification, collaborate)
  
• BioCarta alk in cardiac myocytes: BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) → BMP (BMP7/BMP2/BMP5/BMP10/BMP4) (modification, collaborate)
  
• BioCarta alk in cardiac myocytes: NOGGIN (NOG) → BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) (modification, inhibits)
  
• BioCarta alk in cardiac myocytes: BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) → CHORDIN (CHRD) (modification, activates)
• KEGG TGF-beta signaling pathway: AMH/BMP2/BMP4/BMP5/BMP6/BMP7/BMP8A/BMP8B/GDF5/GDF6/GDF7 → AMHR2/BMPR2 (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: BMP2 → Complex of ACVR1-BMPR2 (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: BMP2 → Complex of BMPR1B-BMPR2 (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: BMP2 → Complex of BMPR1A-BMPR2 (protein-protein, activation)
• NCI Pathway Database BMP receptor signaling: FS (FST) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: FS (FST) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: RGM family (RGMB/RGMA/HFE2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR2 (homodimer) complex (BMPR2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BAMBI (BAMBI) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/SMAD6 complex (MAP3K7-SMAD6) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: GREM1 (GREM1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR2 (homodimer) complex (BMPR2) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: USAG1 (SOSTDC1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR2 (homodimer) complex (BMPR2) → BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → SMAD1 (SMAD1) (modification, collaborate) Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → GADD34/PP1CA complex (ZFYVE16-PPP1R15A-PPP1CA) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: GADD34/PP1CA complex (ZFYVE16-PPP1R15A-PPP1CA) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: SMAD7/SMURF1 complex (SMAD7-SMURF1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD7/SMURF1 complex (SMAD7-SMURF1) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: XIAP (XIAP) → BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) (modification, collaborate)
  Yamaguchi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: XIAP (XIAP) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Yamaguchi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Yamaguchi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/NOG complex (BMP4_BMP2-NOG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/NOG complex (BMP4_BMP2-NOG) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: NOG (NOG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/FETUA complex (BMP4_BMP2-AHSG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/FETUA complex (BMP4_BMP2-AHSG) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: FETUA (AHSG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: CHRD (CHRD) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRD complex (BMP4_BMP2-CHRD) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRD complex (BMP4_BMP2-CHRD) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → CHRDL1 (CHRDL1) (modification, collaborate) Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: CER1 (CER1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CER1 complex (BMP4_BMP2-CER1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CER1 complex (BMP4_BMP2-CER1) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• Reactome Reaction: BMP2 → BMPR2 (reaction) Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
• Reactome Reaction: BMP2 → BMPR2 (indirect_complex) Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Tajima et al., J Biol Chem 2003, Murakami et al., Mol Biol Cell 2003, Shi et al., J Cell Sci 2007, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
• WikiPathways Heart Development: BMP2 → BMPR2/BMPR1A (activation) Prall et al., Cell 2007*
• WikiPathways Bone Morphogenic Protein (BMP) Signalling and Regulation: BMP2 → BMPR2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BMP2 — BMPR2 (physical association, affinity chromatography technology) Liu et al., Mol Cell Biol 1995
• IRef Biogrid Interaction: BMP2 — BMPR2 (direct interaction, pull down) Kirsch et al., EMBO J 2000*
• IRef Biogrid Interaction: BMP2 — BMPR2 (direct interaction, pull down) Gilboa et al., Mol Biol Cell 2000
• IRef Dip Interaction: BMP2 — BMPR2 (direct interaction, surface plasmon resonance) Kirsch et al., EMBO J 2000*
• IRef Dip Interaction: BMP2 — BMPR2 (direct interaction, cross-linking study) Liu et al., Mol Cell Biol 1995
• IRef Hprd Interaction: BMP2 — BMPR2 (in vivo) Kirsch et al., EMBO J 2000*
• IRef Innatedb Interaction: BMP2 — BMPR2 (unknown, -) Weber et al., BMC structural biology 2007*
• IRef Innatedb Interaction: BMP2 — BMPR2 (unknown, -) Yin et al., J Mol Biol 2008*
• MIPS Negatome - no physical interaction between proteins Interaction: BMPR2 — BMP2 (Absence of interaction, cross) Weber et al., BMC structural biology 2007*
• IRef Ophid Interaction: BMP2 — BMPR2 (aggregation, confirmational text mining) Kirsch et al., EMBO J 2000*
• IRef Ophid Interaction: BMP2 — BMPR2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: BMP2 — BMPR2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kano et al., Endocrinology 2005 : Furthermore, intracellular BMP signaling was markedly suppressed by dexamethasone treatment and the expression of ALK-2, ALK-3, and BMPRII was significantly inhibited by dexamethasone
Singhatanadgit et al., J Cell Physiol 2006 : The results showed that although the ligand BMP-2 and growth factors had little effect on BMPR-IA and -II transcript expression, they significantly up-regulated BMPR-IB mRNA specifically
Xia et al., J Biol Chem 2007 : In KGN human ovarian granulosa cells and mouse pulmonary artery smooth muscle cells, BMP2 and BMP4 signaling required BMP receptor type II (BMPRII) , but not activin receptor type IIA (ActRIIA) or ActRIIB, based on changes in BMP signaling by small interfering RNA inhibition of receptor expression ... In KGN human ovarian granulosa cells and mouse pulmonary artery smooth muscle cells, BMP2 and BMP4 signaling required BMP receptor type II (BMPRII) , but not activin receptor type IIA (ActRIIA) or ActRIIB, based on changes in BMP signaling by small interfering RNA inhibition of receptor expression
Hansmann et al., J Clin Invest 2008 (Hypertension, Pulmonary) : Both BMP-2 and a PPARgamma agonist stimulated production and secretion of apoE by SMCs. Using a variety of methods, including short hairpin RNAi in human PASMCs, PAH patient derived BMP-RII mutant PASMCs, a PPARgamma antagonist, and PASMCs isolated from PPARgamma- and apoE-deficient mice, we demonstrated that the antiproliferative effect of BMP-2 was BMP-RII , PPARgamma, and apoE dependent
Wang et al., Biochem Biophys Res Commun 2008 : Moreover, while ATRA induced the expression of BMP-RIA , both BMP-RII and Smad5 mRNA were induced by OM and ATRA
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : Notably, the activation of BMPRII by BMP-2 is required for modulation of Smad activation by NF-kappaB in PC cells
Liu et al., Biochim Biophys Acta 2009 (Hypertension, Pulmonary) : GDF5 and BMP2 stimulate the interaction of BMPR-2 with XIAP thereby reducing the ubiquitination of XIAP, which results in enhanced protein stability
Yang et al., Ann N Y Acad Sci 2010 (Bone Diseases, Developmental) : This study provides an in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts
Valera et al., PloS one 2010 : BMP-2/6 also induced the expression of BMPR2 gene more effectively than BMP-2 or BMP-6 when used at the same concentration and time
Wang et al., Yonsei Med J 2010 : The OM significantly induced the expression of type IA receptor of BMPR ( BMPRIA ) and type II receptor of BMPR ( BMPRII ) in BMSCs after three days of stimulation, while BMP-2 significantly induced BMPRIA and BMPRII in BMSCs after nine or six days of stimulation, respectively
Gamer et al., Genesis 2011 : As BMP signaling is required for endochondral ossification and loss of either Acvr2a or Acvr2b is not associated with deficits in limb development, we hypothesized that BMPR-II would be essential for BMP signaling during skeletogenesis
Park et al., Dev Biol 2012 : The LIM kinase/cofilin pathway mediates non-canonical BMPRII induced de-epithelialization, in response to either cadherin-6B or BMP
Kim et al., Angiogenesis 2012 (Telangiectasia, Hereditary Hemorrhagic) : Conversely, BMP9 blocks EC sprouting and this is dependent on Alk1, BMPRII/ActRII and ID1/ID3