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DCN — EGFR
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
DCN
—
EGFR
(direct interaction, two hybrid)
Santra et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
DCN
—
EGFR
(direct interaction, pull down)
Santra et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
DCN
—
EGFR
(direct interaction, pull down)
Iozzo et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
DCN
—
EGFR
(in vitro)
Santra et al., J Biol Chem 2002*, Iozzo et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
DCN
—
EGFR
(two hybrid)
Santra et al., J Biol Chem 2002*, Iozzo et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
DCN
—
EGFR
(in vivo)
Santra et al., J Biol Chem 2002*, Iozzo et al., J Biol Chem 1999*
-
IRef Ophid Interaction:
DCN
—
EGFR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Iozzo et al., Proc Natl Acad Sci U S A 1999
(Lymphoma, T-Cell...) :
This process is caused by a
decorin mediated activation of the
epidermal growth factor receptor , which leads to a sustained induction of endogenous p21 ( WAF1/CIP1 ) ( the cyclin dependent kinase inhibitor p21 ) and growth arrest
Csordás et al., J Biol Chem 2000
(Calcium Signaling...) :
We demonstrate that
decorin causes a sustained down-regulation of the
EGFR
Zhu et al., J Biol Chem 2005
:
Decorin inhibits the
epidermal growth factor receptor (EGFR) by down regulating its tyrosine kinase activity, thereby blocking the growth of a variety of transformed cells and tumor xenografts
Ma et al., Biol Pharm Bull 2008
:
Meanwhile,
decorin (DCN) , a specific antagonist of EGFR, can target the tumor cells enriched in EGFR and
cause a significant downregulation of
EGFR
Hu et al., Neoplasia (New York, N.Y.) 2009
(Prostatic Neoplasms) :
Moreover, in human prostate cancer cells, we show that
decorin specifically
inhibits EGFR and AR phosphorylation and cross talk between these pathways
Patel et al., J Biol Chem 1998
:
Decorin activates the
epidermal growth factor receptor and elevates cytosolic Ca2+ in A431 carcinoma cells
Iozzo et al., J Biol Chem 1999
:
Exogenous
decorin activates the
epidermal growth factor (EGF) receptor , thereby triggering a signaling cascade that leads to phosphorylation of mitogen activated protein ( MAP ) kinase, induction of p21, and growth suppression