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JUN — MVP
Text-mined interactions from Literome
Yi et al., Cancer Res 2005
:
Major vault protein , in concert with constitutively photomorphogenic 1, negatively
regulates c-Jun mediated
activator protein 1 transcription in mammalian cells ... Similar to COP1,
MVP inhibits c-Jun accumulation and
AP-1 transcription activity ... Taken together, we propose that
MVP , most likely through its interaction with COP1,
suppresses c-Jun mediated
AP-1 transcription under unstressed conditions, thereby preventing cells from undergoing stress response
Ryu et al., Cell Death Differ 2008
:
Also, the level of antiapoptotic B-cell lymphoma protein-2 (Bcl-2) was significantly reduced and the accumulation of
c-Jun increased in
MVP knocked-down senescent HDFs