Gene interactions and pathways from curated databases and text-mining

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JUN — MVP

Text-mined interactions from Literome

Yi et al., Cancer Res 2005 : Major vault protein , in concert with constitutively photomorphogenic 1, negatively regulates c-Jun mediated activator protein 1 transcription in mammalian cells ... Similar to COP1, MVP inhibits c-Jun accumulation and AP-1 transcription activity ... Taken together, we propose that MVP , most likely through its interaction with COP1, suppresses c-Jun mediated AP-1 transcription under unstressed conditions, thereby preventing cells from undergoing stress response
Ryu et al., Cell Death Differ 2008 : Also, the level of antiapoptotic B-cell lymphoma protein-2 (Bcl-2) was significantly reduced and the accumulation of c-Jun increased in MVP knocked-down senescent HDFs