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CRK — EGFR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CRK → EGFR (directlyIncreases, CRK Activity)
  Evidence: 12198159;9642287;9480991
• KEGG ErbB signaling pathway: Complex of EGFR → CRK/CRKL (protein-protein, activation)
• KEGG ErbB signaling pathway: EGFR → CRK/CRKL (protein-protein, activation)
• WikiPathways ErbB Signaling Pathway: EGFR → CRK (activation)
• WikiPathways ErbB Signaling Pathway: EGFR → CRK (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of EGFR-GRB2-STAT5B-CRK
• IRef Bind_translation Interaction: EGFR — CRK (affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Bind_translation Interaction: EGFR — CRK (coimmunoprecipitation) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: EGFR — CRK (physical association, affinity chromatography technology) Katayama et al., Jpn J Cancer Res 1999*
• IRef Biogrid Interaction: EGFR — CRK (physical association, affinity chromatography technology) Ota et al., Cell Signal 1998*
• IRef Biogrid Interaction: EGFR — CRK (direct interaction, unspecified method) Jones et al., Nature 2006
• IRef Biogrid Interaction: EGFR — CRK (physical association, affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: EGFR — CRK (physical association, affinity chromatography technology) Hashimoto et al., J Biol Chem 1998*
• IRef Biogrid Interaction: EGFR — CRK (direct interaction, enzymatic study) Hashimoto et al., J Biol Chem 1998*
• IRef Hprd Interaction: Complex of 73 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Hprd Interaction: Complex of 73 proteins (in vivo) Kao et al., J Biol Chem 2001
• IRef Hprd Interaction: EGFR — CRK (in vitro) Endo et al., J Biol Chem 2002*, Abassi et al., EMBO J 2002*, Wang et al., Oncogene 1996*, Koval et al., Biochem J 1998, Hashimoto et al., J Biol Chem 1998*
• IRef Hprd Interaction: EGFR — CRK (in vivo) Endo et al., J Biol Chem 2002*, Abassi et al., EMBO J 2002*, Wang et al., Oncogene 1996*, Koval et al., Biochem J 1998, Hashimoto et al., J Biol Chem 1998*
• IRef Intact Interaction: EGFR — CRK (direct interaction, protein array) Jones et al., Nature 2006
• IRef Ophid Interaction: EGFR — CRK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Nicholl et al., J Vasc Surg 2005 : Inhibition of EGFR reduced both ERK1/2 and p38 MAPK activation
Kuwahara et al., Am J Physiol Lung Cell Mol Physiol 2006 : We conclude that NE increases IL-8 transcription through p38/NF-kappaB activation via EGFR transactivation
Jiang et al., J Ocul Pharmacol Ther 2006 : EGF induced cell migration in a dose dependent manner ; EGF induced EGFR phosphorylation and downstream activation of c-Jun N-terminal protein kinase (JNK), p38 MAP kinase ( p38 ) , extracellular signal regulated kinase ( ERK1/2 ) and AKT, were inhibited by PD153035 ( EGFR inhibitor ), JNKi ( JNK inhibitor ), SB203580 ( p38 inhibitor ), U0126 ( MEK/ERK inhibitor ), and LY294002 ( PI3K/AKT inhibitor ), respectively
Harrington et al., Obesity (Silver Spring) 2007 : Our results show that EGFR homodimers mediate action of EGF at high abundance, but at low abundance, EGF promotes differentiation through EGFR/EB2R heterodimer activation of Src and p38
Taub et al., Mol Biol Cell 2007 (MAP Kinase Signaling System) : Continuous EGFR signaling from late endosomes caused sustained extracellular signal regulated kinase and p38 signaling and resulted in hyperactivation of nuclear targets, such as Elk-1
Wakasaki et al., Neoplasia (New York, N.Y.) 2010 (Carcinoma, Squamous Cell...) : Little is known, however, about a role of CIN85 in EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Schroeder et al., Mol Biol Cell 2012 : In this study we show that EGFR activation leads to a pronounced src mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination