◀ Back to TNF
SPHK2 — TNF
Text-mined interactions from Literome
Xia et al., J Biol Chem 1999
(Arteriosclerosis) :
We now show that HDL profoundly inhibit
TNF stimulated
sphingosine kinase activity in endothelial cells resulting in a decrease in sphingosine 1-phosphate production and adhesion protein expression
Vann et al., J Biol Chem 2002
(Glioma) :
TNF-alpha also
stimulates sphingosine kinase , the enzyme that phosphorylates sphingosine to form sphingosine-1-phosphate ( SPP ), a further metabolite of ceramide
Mastrandrea et al., Diabetes 2005
:
IL-1beta or
TNF-alpha increased islet
SPHK activity within 15 min to 1 h ; activity remained elevated after 8 h. SPHK2 was the predominant active isoform in INS-1 cells ; little or no SPHK1 activity was detected ... IL-1beta, but not
TNF-alpha ,
induced relative SPHK1a mRNA expression levels within 1 h in islets, whereas
SPHK2 mRNA levels were unchanged ... Thus, IL-1beta and
TNF-alpha induced an early and sustained
increase in
SPHK activity in INS-1 cells and isolated islets, suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines
Zhi et al., J Cell Physiol 2006
(Inflammation) :
We show that
TNFalpha rapidly
triggers S1P generation and activation of
SPHK
Radeff-Huang et al., J Biol Chem 2007
(Brain Neoplasms...) :
Tumor necrosis factor-alpha (TNF-alpha) has been shown to
activate sphingosine kinase ( SphK ) in a variety of cell types ... Signaling mechanisms through which
SphK mediated the effect of
TNF-alpha on DNA synthesis were then examined
Chandru et al., Gene 2007
:
Dimethylsphingosine, an inhibitor of
sphingosine kinase , partially
inhibited TNF-alpha induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction
Gurgui et al., Cell Signal 2010
:
Although our experimental data clearly show the mediatory
role of
sphingosine kinase ( SK ) -derived S1P in the
TNF-alpha and the LPS induced activation of NF-kB, exogenously added S1P failed to trigger this transcription factor