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LEP — RENBP

Text-mined interactions from Literome

Lee et al., J Cell Biochem 2004 : We concluded that AGE induced JAK2 to increase leptin while leptin induced JAK2 to increase CTGF induced mitogenesis and type I collagen protein expression in NRK-49F cells
Horiuchi et al., Ann N Y Acad Sci 2005 (Diabetic Nephropathies) : In this study, we focused on two AGE receptors-specifically, the role of SR-A in pathogenesis of diabetic nephropathy and the role of CD36 in AGE induced downregulation of leptin by adipocytes ... AGE induced downregulation of leptin was protected by N-acetyl-cysteine, an antioxidant
Unno et al., Ann N Y Acad Sci 2005 (Metabolic Syndrome X) : The purpose of this study was to examine effects of AGE ligands on leptin expression in adipocytes ... These results indicate that the ligand interaction of GA-BSA with CD36 leads to downregulation of leptin expression in 3T3-L1 adipocytes, suggesting that AGE induced leptin downregulation is linked to reduction of the insulin sensitivity in metabolic syndrome