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LEP — SH2B1

Pathways - manually collected, often from reviews:

• Reactome Reaction: LEP → SH2B1 (reaction) Nishi et al., Mol Cell Biol 2005, Li et al., Mol Endocrinol 2007
• Reactome Reaction: LEP → SH2B1 (indirect_complex) Szanto et al., Proc Natl Acad Sci U S A 2000, Martín-Romero et al., Cell Immunol 2001, Duan et al., J Biol Chem 2004, Nishi et al., Mol Cell Biol 2005, Li et al., Mol Endocrinol 2007, Hill et al., J Clin Invest 2008, Buettner et al., Nat Med 2008, Bjørbaek et al., J Biol Chem 1997

Text-mined interactions from Literome

Li et al., Endocrinology 2006 (Body Weight...) : SH2-B and APS, two members of a pleckstrin homology and SH2 domain containing adaptor family, promote both insulin and leptin signaling in a similar fashion in cultured cells
Li et al., Endocrinology 2007 : In mice, SH2B1 regulates energy and glucose homeostasis by enhancing leptin and insulin sensitivity
Li et al., Mol Endocrinol 2007 : SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation dependent and -independent mechanisms ... Leptin promoted the interaction of SH2B1 with IRS1 ... Leptin stimulated SH2B1-JAK2 interaction, mediated by the SH2 domain of SH2B1 and phospho-Tyr ( 813 ) in JAK2, promotes JAK2 activation, thus globally enhancing leptin signaling
Rider et al., Mol Endocrinol 2009 : The Src homology 2 (SH2) domain containing adapter protein SH2B1beta plays a role in severe obesity, leptin and insulin resistance, and infertility