Gene interactions and pathways from curated databases and text-mining

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IL6 — JAK3

Pathways - manually collected, often from reviews:

  • BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) → STAT3 (modification, activates)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → STAT3 (modification, activates)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → JAKs (JAK2/JAK1/JAK3) (modification, collaborate)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  • BioCarta il 6 signaling pathway: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  • BioCarta role of erbb2 in signal transduction and oncology: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  • BioCarta role of erbb2 in signal transduction and oncology: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) (modification, collaborate)
  • BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) (modification, collaborate)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)

Text-mined interactions from Literome

Wang et al., Oncogene 2000 : PD180970 did not affect MAPK activation by PDGF or the JAK dependent activation of Stat3 by interleukin-6
Song et al., Zhonghua Xue Ye Xue Za Zhi 2000 (Multiple Myeloma) : The biological function of IL-6 on Sko-007 cells is mediated by the activation of Jak/STAT and Ras/NF-IL-6 signal transduction pathways
Kuo et al., Oncogene 2001 : In Hep3B cells, the JAK/STAT3 , ERK, and PI 3-K/Akt pathways were activated by IL-6 stimulation
Song et al., Zhonghua Zhong Liu Za Zhi 2001 (Multiple Myeloma) : ( 1 ) IL-6 could promote the proliferation of U266 cells, ( 2 ) both JAK/STAT and Ras/NF-IL-6 signal transduction pathways were activated by IL-6 in the U266 cells and ( 3 ) Cell proliferation and activation of the two IL-6 signal transduction pathways were inhibited by Forskolin ; down regulating the actiration of these two signal transduction pathways at the same time
Legendre et al., J Biol Chem 2003 : JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes
Mangan et al., Blood 2004 : Mechanisms associated with IL-6 induced up-regulation of Jak3 and its role in monocytic differentiation
Siavash et al., Br J Cancer 2004 (Carcinoma, Squamous Cell...) : Abrogation of IL-6 mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ ( 2 ) in oral squamous carcinoma cells ... Importantly, 15d-PGJ ( 2 ) selectively abrogated constitutive and IL-6 mediated JAK phosphorylation without affecting EGFR activated levels ... Our findings provide the first evidence for 15d-PGJ ( 2 ) -mediated downregulation of constitutive and IL-6 induced JAK signalling in cancer and support that JAK inhibition and suppression of EGFR independent Stat3 activation by 15d-PGJ ( 2 ) represent a promising approach for induction of apoptosis in oral SCC cells
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Kimura et al., Proc Natl Acad Sci U S A 2005 : Suppressor of cytokine signaling-1 selectively inhibits LPS induced IL-6 production by regulating JAK-STAT
Lee et al., Mol Cancer Ther 2006 (Carcinoma, Squamous Cell...) : We conclude that SOCS-1 methylation status can differentially affect STAT3 activation by IL-6R and EGFR through JAK or MEK in different HNSCC and response to pharmacologic antagonists
O'Hara et al., Biochem J 2007 : Inhibition with siRNA ( small interfering RNA ) targeting the SFK Lck, but not dominant negative JAK ( Janus kinase ), prevented Cr ( VI ) -stimulated phosphorylation of both STAT3 isoforms and induction of IL-6
Gong et al., Mol Nutr Food Res 2009 (Prostatic Neoplasms) : Moreover, an antioxidant reagent, N-acetyl-L-cysteine (NAC) which suppresses reactive oxygen species ( ROS ) generation, reversed the early inhibitory effects of PEITC on cell proliferation, constitutive or IL-6 mediated JAK-STAT3 phosphorylation in PCa cells
Radtke et al., J Cell Sci 2010 : We show that p38, activated by IL-1beta, TNFalpha or environmental stress, impairs IL-6 induced JAK/STAT signalling through phosphorylation of the common cytokine receptor subunit gp130 and its subsequent internalisation and degradation
Tanabe et al., Journal of neuroinflammation 2010 (Glioma) : The Janus family of tyrosine kinase ( JAK ) inhibitor I, an inhibitor of JAK 1, 2 and 3, attenuated TNF-alpha induced phosphorylation of STAT3 and significantly reduced TNF-alpha stimulated IL-6 release
Liu et al., Neurotox Res 2011 : These results suggest that IL-6 protects neurons against NMDA induced apoptosis, and that the IL-6 neuroprotection is jointly mediated by JAK-STAT3 and PI3K-Akt signaling pathways
Ngo et al., Nature 2011 (Burkitt Lymphoma...) : The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity, IRAK1 phosphorylation, NF-?B signalling, JAK kinase activation of STAT3, and secretion of IL-6 , IL-10 and interferon-ß
Tanabe et al., Journal of neuroinflammation 2011 : The IL-1ß stimulated levels of IL-6 were suppressed by wedelolactone ( an inhibitor of I?B kinase ), SP600125 ( an inhibitor of SAPK/JNK ), and JAK inhibitor I ( an inhibitor of JAK 1, 2 and 3 )
Dittrich et al., Molecular bioSystems 2012 : Misregulated interleukin-6 (IL-6) induced Jak/STAT signaling contributes to many diseases
Nam et al., J Pept Sci 2012 : Inhibition of JAK ( STAT1/STAT5 kinase ) with AG490 markedly reduced the production of IL-6 and TNF-a in macrophages
Russell et al., Islets 2013 : Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic ß-cells
Lai et al., PloS one 2013 : Additionally, IL-6 mediated angiotensinogen expression through the Janus kinase ( JAK ) /signal transducer and activator of transcription 3 ( STAT3 ) and JAK/p38 signaling ... IL-6 mediated signaling, JAK2 , STAT3 and p38 inhibitors reduced angiotensinogen expression in the partially hepatectomized mice
Leven et al., Blood Cells Mol Dis 1997 : Studies on protein phosphorylation revealed that IL6 , but not TPO, stimulated phosphorylation of JAK1, JAK2 and MAP kinase
Sengupta et al., Proc Natl Acad Sci U S A 1998 : These results demonstrate an ERK mediated mechanism for inhibiting IL-6 induced Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway