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EPHB2 — PAK4
Text-mined interactions from Literome
Penzes et al., Neuron 2003
:
Overexpression of dominant negative
EphB receptor, catalytically inactive kalirin, or dominant negative Rac1, or
inhibition of
PAK eliminates ephrin induced spine development
Sundberg-Smith et al., J Biol Chem 2005
:
Interestingly, deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene, indicating that association between
PAK and ERK is
required to facilitate
ERK signaling
Stockton et al., Mol Biol Cell 2007
(Inflammation) :
Erk in lipopolysaccharide (LPS) treated mouse lung is activated in a
PAK dependent manner in several cell types, most prominently vascular endothelium
Chow et al., PloS one 2010
(Cell Transformation, Neoplastic...) :
However, in tumors, loss of
Pak activity does not
reduce Erk or Akt activity, two signaling proteins that are thought to mediate Pak function in growth factor pathways
De la Mota-Peynado et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Erk3 protein is known to shuttle between the cytoplasm and the nucleus, and we showed that selective inhibition of class I
Pak kinase activity in cells
promoted increased nuclear accumulation of
Erk3
Lu et al., Neoplasma 2013
(Endometrial Neoplasms...) :
p21 activated kinase 4 regulation of endometrial cancer cell migration and invasion
involves the
ERK1/2 pathway mediated MMP-2 secretion
Yablonski et al., EMBO J 1998
:
TCR mediated activation of
Erk2 was also
inhibited by dominant negative
Pak