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EPHB2 — RHO

Text-mined interactions from Literome

Tang et al., Mol Cell Biol 1999 (Cell Transformation, Neoplastic) : All combinations of Rac/Raf and Ras/Raf and Rho/Raf effector mutants that transform cells cooperatively stimulated ERK
Aikawa et al., Circ Res 1999 (Cardiomegaly) : Overexpression of the Rho GDP dissociation inhibitor (Rho-GDI) , dominant negative mutants of RhoA ( DNRhoA ), or DNRac1 significantly inhibited stretch induced activation of transfected ERK2 ... Overexpression of Rho-GDI or DNRhoA did not affect angiotensin II-induced activation of ERK
Matrougui et al., Arterioscler Thromb Vasc Biol 2001 : The purpose of the present study was to investigate the involvement of Rho-kinase and the actin filament network in Ang II- and pressure induced ERK1/2 activation, as well as in the contractile response induced by Ang II ... Selective inhibition of Rho-kinase by Y-27632 ( 10 micromol/L ) and selective disruption of the actin filament network by cytochalasin B ( 10 micromol/L ) both decreased the Ang II-induced contraction by 78+/-1.2 % and 87+/-1.9 %, respectively, and significantly diminished ERK1/2 activity ... These results indicate that whereas pressure induced ERK1/2 activation requires an intact actin filament network, but not Rho-kinase , the activation of ERK1/2 and the contraction induced by Ang II require both Rho-kinase and an intact actin filament network in isolated, intact mesenteric resistance arteries
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : Rac and Cdc42, but not Ras or Rho , were responsible for this MAPK/ERK activation
Penzes et al., Neuron 2003 : Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
Budnik et al., Mol Endocrinol 2003 : Surprisingly, functional inhibition of Rho-GTPase , in C3-exotoxin lipofected cells, markedly reduced LPA stimulated phosphorylation of ERK , without affecting the EGF induced stimulation of MAPK
Roovers et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling, but only Rho kinase inhibition allowed for the induction of cyclin D1 and activation of cdk4 via Rac/Cdc42
Liu et al., Circ Res 2004 : Rho kinase induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin
Galaria et al., J Surg Res 2004 : Rho regulates ERK1/2 activation through MEK1/2, while Rho kinase negatively modulates ERK1/2 in a MEK1/2 independent manner and regulates p38 ( MAPK ) through MKK3/6
Zhao et al., Mol Pharmacol 2006 : It is interesting that the nuclear accumulation of ERK1/2 and Elk phosphorylation was completely blocked by dominant negative Rho , Y27632, PP1, and latrunculin B, indicating that the Rho/ROCK pathway, Src kinase, and the actin cytoskeleton were required in this process ... In summary, these results demonstrate that Src, Rho/ROCK , and an intact cytoskeleton contribute to overall ERK1/2 activation in SDF-1 stimulated cells and are indispensable for nuclear translocation of ERK1/2 and activation of transcription factors
Sterpetti et al., Am J Physiol Gastrointest Liver Physiol 2006 (Carcinoma, Hepatocellular...) : Lbc stably transfected hepatocarcinoma cells exhibit increased proliferation and levels of ERK and cyclin D1 activation, which are blocked by a Rho inhibitor
Chen et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Peroxisome proliferator activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase dependent activation of ERK1/2
Foltenyi et al., Nat Neurosci 2007 : Our results demonstrate that rhomboid (Rho)- and Star mediated activation of EGFR and ERK signaling increases sleep in a dose dependent manner, and that blockade of rhomboid ( rho ) expression in the nervous system decreases sleep
Samarakoon et al., J Mol Cell Cardiol 2008 : Thus, two distinct pathways involving the EGFR/pp60(c-src)/MEK-ERK pathway and Rho/ROCK dependent SMAD2 activation are required for TGF-beta1 induced PAI-1 expression in VSMC
Schramp et al., J Cell Biol 2008 (MAP Kinase Signaling System) : In Src transformed cells, ERK5 induced the expression of a Rho GTPase activating protein (RhoGAP) , RhoGAP7/DLC-1, via activation of the transcription factor myocyte enhancing factor 2C, and RhoGAP7 expression restored podosome formation in ERK5-deficient cells
Waheed et al., Am J Physiol Cell Physiol 2010 : Importantly, inhibition of ERK prevented the depolarization induced activation of Rho