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CCND3 — CDK4

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: CDKN1B/CDKN1C → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: PCNA → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2B → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: Complex of CCND1-CCND2-CCND3-CDK4-CDK6 → RBL1/RBL2 (protein-protein, inhibition)
• KEGG Cell cycle: Complex of CCND1-CCND2-CCND3-CDK4-CDK6 → RB1 (protein-protein, inhibition)
• KEGG Cell cycle: CDKN2A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2C → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2D → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG p53 signaling pathway: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → HDAC1 (HDAC1) (modification, inhibits) Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, inhibits)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: p16INK4a (CDKN2A) → CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) (modification, collaborate)
  Fåhraeus et al., Curr Biol 1996
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: p16INK4a (CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Fåhraeus et al., Curr Biol 1996
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Fåhraeus et al., Curr Biol 1996
  Evidence: physical interaction
• WikiPathways Human Thyroid Stimulating Hormone (TSH) signaling pathway: CDK4 → CCND3 (activation)
• WikiPathways Human Thyroid Stimulating Hormone (TSH) signaling pathway: CCND3 → CDK4 (activation)
• WikiPathways miRNA Regulation of DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways miRNA Regulation of DNA Damage Response: CDC25A → Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 (activation)
  
• WikiPathways DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways DNA Damage Response: CDC25A → Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: CDK4 — CCND3 (array technology) Ramachandran et al., Science 2004
• IRef Bind_translation Interaction: CDK4 — CCND3 (coimmunoprecipitation) Laman et al., EMBO J 2005
• IRef Biogrid Interaction: CDK4 — CCND3 (physical association, affinity chromatography technology) Lin et al., Oncogene 2001*
• IRef Biogrid Interaction: CDK4 — CCND3 (physical association, affinity chromatography technology) Zhang et al., Endocrinology 1999*
• IRef Biogrid Interaction: CDK4 — CCND3 (direct interaction, two hybrid) Rual et al., Nature 2005
• IRef Biogrid Interaction: CDK4 — CCND3 (physical association, affinity chromatography technology) Datta et al., Cell Growth Differ 1998
• IRef Biogrid Interaction: CDK4 — CCND3 (physical association, affinity chromatography technology) García-Morales et al., Mol Cancer Ther 2006*
• IRef Biogrid Interaction: CDK4 — CCND3 (physical association, affinity chromatography technology) Bockstaele et al., Mol Cell Biol 2006
• IRef Biogrid Interaction: CDK4 — CCND3 (direct interaction, pull down) Ramachandran et al., Science 2004
• IRef Biogrid Interaction: CDK4 — CCND3 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: CDK4 — CCND3 (physical association, affinity chromatography technology) Arsenijevic et al., Biochem J 2004*
• MIPS CORUM CCND3-CDK4 complex: CCND3-CDK4 complex complex (CCND3-CDK4) Lundberg et al., Mol Cell Biol 1998*
• MIPS CORUM CyclinD3-CDK4-CDK6 complex: CyclinD3-CDK4-CDK6 complex complex (CCND3-CDK4-CDK6) Wang et al., Cell Growth Differ 1996*
• MIPS CORUM CyclinD3-CDK4-CDK6-p21 complex: CyclinD3-CDK4-CDK6-p21 complex complex (CCND3-CDK4-CDK6-CDKN1A) Wang et al., Cell Growth Differ 1996*
• IRef Corum Interaction: Complex of CDKN1A-CDK4-CCND3-CDK6 (association, anti tag coimmunoprecipitation) Wang et al., Cell Growth Differ 1996*
• IRef Corum Interaction: Complex of CCND3-CDK4-CDK6 (association, anti tag coimmunoprecipitation) Wang et al., Cell Growth Differ 1996*
• IRef Corum Interaction: CDK4 — CCND3 (association, coimmunoprecipitation) Lundberg et al., Mol Cell Biol 1998*
• IRef Dip Interaction: CDK4 — CCND3 (direct interaction, light scattering) Takaki et al., Proc Natl Acad Sci U S A 2009*
• IRef Dip Interaction: CDK4 — CCND3 (direct interaction, x-ray crystallography) Takaki et al., Proc Natl Acad Sci U S A 2009*
• IRef Dip Interaction: CDK4 — CCND3 (direct interaction, molecular sieving) Takaki et al., Proc Natl Acad Sci U S A 2009*
• IRef Hprd Interaction: CCND3 — CDK4 (in vitro) Zhang et al., Endocrinology 1999*, Decker et al., Leukemia 2002*, Ramachandran et al., Science 2004
• IRef Hprd Interaction: CCND3 — CDK4 (in vivo) Zhang et al., Endocrinology 1999*, Decker et al., Leukemia 2002*, Ramachandran et al., Science 2004
• IRef Intact Interaction: CDK4 — CCND3 (direct interaction, protein array) Ramachandran et al., Science 2004
• IRef Intact Interaction: CDK4 — CCND3 (physical association, anti bait coimmunoprecipitation) Decker et al., Leukemia 2002*
• IRef Intact Interaction: CDK4 — CCND3 (direct interaction, inferred by curator) Hermjakob et al., Nucleic Acids Res 2004
• IRef Intact Interaction: CDK4 — CCND3 (physical association, two hybrid pooling approach) Rual et al., Nature 2005
• IRef Intact Interaction: CDK4 — CCND3 (physical association, two hybrid) Yu et al., Nat Methods 2011
• IRef Intact Interaction: CDK4 — CCND3 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: CDK4 — CCND3 (physical association, anti bait coimmunoprecipitation) LaBaer et al., Genes Dev 1997*
• IRef Ophid Interaction: CDK4 — CCND3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CDK4 — CCND3 (aggregation, confirmational text mining) Ramachandran et al., Science 2004

Text-mined interactions from Literome

Shimizu et al., Oncogene 2000 (Leukemia, Myeloid, Acute) : We also showed that an increase in CDK2 bound p27 and CDK4 bound p18 are caused by treatment with ATRA and a decrease in CDK6 bound cyclin D3 is induced synergistically by treatment with both reagents
Coulonval et al., Exp Cell Res 2003 : In the presence of TSH, transforming growth factor beta ( TGFbeta ) did not affect the assembly of cyclin D3-CDK4, but it strongly inhibited the pRb-kinase activity associated with both cyclin D3 and p27, not only by preventing the nuclear import of cyclin D3-CDK4 and its binding to p27, but also by inhibiting CDK4 phosphorylation within residual p27 bound cyclin D3-CDK4 complexes
Hleb et al., J Biol Chem 2004 : The overall effect of rapamycin on cyclin D3 leads to impaired formation of active complexes with Cdk4 or Cdk6 and subsequent inhibition of cyclin D3/CDK kinase activity