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PCBD1 — TNFSF10

Text-mined interactions from Literome

Bretz et al., J Biol Chem 1999 (Papilloma...) : Despite the expression of TRAIL receptors death receptor 4 and death receptor 5, purified TRAIL could not induce programmed cell death (PCD) in any of the thyroid follicular cells examined ... This suggested that despite the presence of a labile inhibitor of the TRAIL pathway, TRAIL could mediate PCD under appropriate conditions
Thon et al., Exp Cell Res 2006 : Here, we demonstrate for the first time that the single murine receptor for (TNF) related apoptosis inducing ligand ( mTRAIL-R2 ) can induce a caspase independent form of PCD with necrosis-like features in addition to apoptosis ... Cells overexpressing acid ceramidase ( AC ), an enzyme that metabolizes the sphingolipid ceramide, show enhanced survival from TRAIL induced caspase independent PCD but not from apoptosis, implicating a function of ceramide as a key mediator in caspase independent PCD ( but not apoptosis ) induced by mTRAIL-R2