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CCL3 — CCR2
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CCR2
→
CCL3
(increases, CCL3 Activity)
Evidence: The identification of the heptahelical receptors CXCR1 and CXCR2 for IL-8 and its homologues [14, 15], as well as CCR1 and CCR2 for the CC chemokines MIP-1?/regulated on activation normal T cell expressed and secreted (RANTES; CC ligand 5) and monocyte chemotactic protein (MCP) 1 [16, 17],
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KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
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WikiPathways Chemokine signaling pathway:
CCL19/CCL27/CXCL3/CXCL10/XCL1/CXCL9/CCL21/CCL1/CCL11/CCL7/CCL17/CCL20/CCL22/CCL25/CCL27/CCL3/CCL4/CCL5/CCL15/CCL7/CCL15/CXCL3/CXCL5/CX3CL1/CXCL12/CCL19/CCL26/CXCL13/CXCL11/CCL24/PF4/CCL28/CXCL14/PPBP/CCL21/CXCL16
→
CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6
(activation)
Text-mined interactions from Literome
Solomon et al., Xenotransplantation 2003
:
The impeded migration of leukocytes into xenografts in CCR2-/- hosts was associated with delayed intragraft expression of MCP-1 and RANTES mRNA ; absence of
MCP-1/CCR2 mediated signaling
led to enhanced intragraft expression of MCP-1,
MIP-1alpha and MIP-1beta mRNA
Corbin et al., J Neurovirol 2006
(Nervous System Diseases...) :
Additionally,
CCR1 deficiency did not
affect the up-regulation of its ligands,
CCL3 , CCL5, or CCL7