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HIF1A — TXN

Text-mined interactions from Literome

Welsh et al., Mol Cancer Ther 2003 (Breast Neoplasms...) : The redox protein thioredoxin-1 (Trx-1) , which is found at high levels in many human cancers, increases both aerobic and hypoxia induced HIF-1alpha protein in cells leading to increased expression of HIF regulated genes
Kim et al., Int J Oncol 2005 (Neoplasms...) : Moreover, transfection of Trx caused a dramatic increase in HIF-1alpha protein level under hypoxic condition
Csiki et al., Cancer Res 2006 (Carcinoma, Non-Small-Cell Lung...) : We also show that thioredoxin-1 stabilizes HIF-1alpha to induce hypoxia-responsive genes under normoxic conditions
Zhou et al., J Biol Chem 2007 : In this study, we present evidence that overexpression of mitochondria located thioredoxin 2 (Trx2) attenuated hypoxia evoked HIF-1alpha accumulation, whereas cytosolic thioredoxin 1 (Trx1) enhanced HIF-1alpha protein amount
Zhou et al., Free Radic Biol Med 2008 (MAP Kinase Signaling System) : In this study, we present evidence that overexpression of mitochondrial located thioredoxin 2 (Trx2) or thioredoxin reductase 2 (TrxR2) attenuated NO-evoked HIF-1alpha accumulation and transactivation of HIF-1 in HEK293 cells