Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Shin et al., Biochim Biophys Acta 2008 (Stomach Neoplasms) : Here, we demonstrate that vitamin D3 up-regulated protein 1 ( VDUP1 ) associates with the beta-domain of pVHL and enhances the interaction between pVHL and HIF1alpha to promote the nuclear export and degradation of HIF1alpha hypoxia-independently
Baker et al., Pancreas 2008 (Carcinoma, Pancreatic Ductal...) : Thioredoxin interacting protein was induced during hypoxia in pancreatic cancer cells in a HIF-1alpha dependent manner ... Thioredoxin interacting protein , a putative tumor suppressor gene, is induced in response to hypoxia in a HIF-1alpha dependent manner in pancreatic cancer cells, resulting in increased apoptosis and increased sensitivity to platinum anticancer therapy