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EPO — LYN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer) complex (EPO-EPOR)
→
LYN (LYN)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer) complex (EPO-EPOR)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
LYN (LYN)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, activates)
Penta et al., J Biol Chem 1995
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, activates)
Ren et al., J Biol Chem 1994*
Evidence: assay
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
→
p38 alpha (MAPK14)
(modification, activates)
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, activates)
Penta et al., J Biol Chem 1995
Evidence: assay, other species
Text-mined interactions from Literome
Tilbrook et al., Cancer Res 2001
(Cell Transformation, Neoplastic...) :
In normal erythroid progenitors,
erythropoietin enhanced phosphorylation of
Lyn ; moreover, exogenous Lyn increased colony forming unit-erythroid, but not burst forming uniterythroid, colonies from normal progenitors, demonstrating a stage-specific effect of the kinase
Boudot et al., Biochem Biophys Res Commun 2003
:
Moreover
Epo activated
Lyn phosphorylates in vitro PLC-gamma 2 immunoprecipitated from unstimulated cells
Kosmider et al., PloS one 2009
(Leukemia) :
Furthermore, enforced expression of
Lyn in the cell lines increased cell proliferation in
response to
Epo , but reduced cell growth in response to SCF in accordance with Lyn ability to down-regulate Kit expression
Slavova-Azmanova et al., Blood 2013
(Anemia, Hemolytic) :
Gain-of-function Lyn induces anemia : appropriate
Lyn activity is
essential for normal erythropoiesis and
Epo receptor signaling