◀ Back to RAC1

IRF6 — RAC1

Text-mined interactions from Literome

Woo et al., Mol Cells 2002 (MAP Kinase Signaling System) : Our results showed that LPS induced the activation of ERK and p38 MAP kinase in a Rac dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation ... We also observed that LPS caused a time dependent activation of Rac1 ... In addition, our results have shown that pretreatment with herbimycin or wortmannin dramatically inhibited Rac1 activation induced by LPS
Schmeck et al., Inflammation 2003 : Therefore, RhoA/Rac1/Cdc42 contribute to NF-kappaB dependent LPS- and TNFalpha induced expression of PGHS-2 in EC but had no effect on the activity of expressed COX-1 and COX-2
Patel et al., J Surg Res 2004 : We have shown that lipopolysaccharide (LPS) stimulation leads to Rac activation in THP-1 cells
Equils et al., J Immunol 2004 : The roles of Rac1 and TIRAP in LPS activation of HIV replication is not known ... In the present study we show that LPS stimulation of human microvessel endothelial cells leads to Rac1 activation
Kawahara et al., Am J Physiol Cell Physiol 2005 : In addition, H. pylori LPS activated Rac1 ; i.e., it converted Rac1 to the GTP bound state ... A phosphoinositide 3-kinase inhibitor, LY-294002, blocked H. pylori LPS induced Rac1 activation and O2- generation without interfering with the expression of Nox1 and NOXO1 mRNA
Basak et al., J Biol Chem 2005 (MAP Kinase Signaling System) : To the best of our knowledge our studies show for the first time that LPS induced Rac1/PAK1 signaling leading to caspase-1 phosphorylation is crucial for caspase-1 activation
Thakur et al., J Leukoc Biol 2006 : LPS rapidly increased Rac1-guanosinetriphosphatase ( GTPase ) activity and p67(phox) translocation to the plasma membrane in Kupffer cells from pair fed rats
Kamon et al., EMBO J 2006 : LPS increased the activity of RhoB, but not of RhoA, Cdc42, or Rac1/2 in a manor dependent on LPS-TRIF- but not LPS-Myd88 signaling
Zhang et al., J Cell Mol Med 2011 (Endotoxemia...) : The aim of this study was to investigate the role of Rac1 in TNF-a expression and cardiac dysfunction during endotoxemia and to determine the involvement of phosphoinositide-3 kinase (PI3K) in lipopolysaccharide (LPS) induced Rac1 activation ... Our results showed that LPS induced Rac1 activation and TNF-a expression in cultured neonatal mouse cardiomyocytes
Yao et al., Biochim Biophys Acta 2011 (Lung Injury) : LPS activated both Rac1 and Rac2, but not CDC42 or RhoA activities in lungs, and specific inhibition of Rac activities by NSC23766 effectively alleviated LPS induced injury