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JAK2 — NOS2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12-mediated signaling events:
NOS2 (NOS2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
NOS2 (NOS2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, activates)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
Text-mined interactions from Literome
Nakashima et al., J Am Soc Nephrol 1999
:
The effect of NF-kappaB release and its inhibition on nitrite production and the
involvement of
Janus kinase 2 (JAK2) in
inducible nitric oxide synthase (iNOS) induction were investigated ... ( 4 )
iNOS promoter activity was measured in the
presence of AG490 or
JAK2 antisense oligonucleotides ... AG490 and
JAK2 antisense oligonucleotides
suppressed iNOS promoter activity ... It can be concluded that ( 1 ) iNOS can be induced without active NF-kappaB ; ( 2 ) Dex, acetylsalicylic acid, and PDTC inhibit only p65 ; and ( 3 )
JAK2 is
involved in
iNOS induction, and the contribution of JAK2 to nitrite production is greater than that of NF-kappaB
Cruz et al., Am J Physiol 1999
(MAP Kinase Signaling System) :
Our results show that
JAK2 plays a major role in the induction of
iNOS in FSDC
Cruz et al., Nitric Oxide 2001
:
LPS induction of I kappa B-alpha degradation and
iNOS expression in a skin dendritic cell line is
prevented by the
janus kinase 2 inhibitor, Tyrphostin b42 ... In FSDC the expression of
iNOS protein and nitric oxide production, in response to the lipopolysaccharide (LPS) stimulus ( 5 microg/ml ), is
inhibited by the specific inhibitor of the
JAK2 , tyrphostin B42 with an half maximal inhibitory concentration ( IC ( 50 ) ) of 9.65 microM
Dell'Albani et al., J Neurosci Res 2001
(Central Nervous System Diseases) :
Inhibition experiments showed that
JAK2 and STAT1 alpha/beta tyrosine phosphorylation were
necessary for IFN gamma mediated
iNOS induction in astroglial cells
Doi et al., Atherosclerosis 2002
:
Cytokine activated
Jak-2 is
involved in inducible
nitric oxide synthase expression independent from NF-kappaB activation in vascular smooth muscle cells
Yu et al., J Biol Chem 2003
:
JAK2/STAT3 , not ERK1/2,
mediates interleukin-6 induced activation of inducible
nitric-oxide synthase and decrease in contractility of adult ventricular myocytes
Sareila et al., Mediators Inflamm 2006
:
We investigated the
effects of
Janus kinase ( JAK ) inhibitors, AG-490 and WHI-P154, on
iNOS expression and NO production in J774 murine macrophages stimulated with interferon-gamma (IFN-gamma)
Choy et al., Proc Natl Acad Sci U S A 2007
:
JAK signaling, initiated during T cell activation,
inhibits iNOS expression
Tsoyi et al., Cell Signal 2008
:
However, AG490, a specific
JAK-2/STAT-1 inhibitor, efficiently
prevented LPS mediated
iNOS induction but not the induction of COX-2, and CKD712 completely blocked STAT-1 phosphorylation by LPS, suggesting that the NF-kappaB and JAK-2/STAT-1 pathways but not the JNK pathway are important for CKD712 action
Wu et al., Br J Pharmacol 2009
:
Effects of tripterine were investigated on endothelial barrier function,
inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity,
activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and
Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma ... Our results indicate that, by preventing
Jak2 dependent
induction of
iNOS and Nox1, tripterine inhibits peroxynitrite precursor synthesis, attenuates the increased activity of PP2A and consequently protects endothelial barrier function
Do et al., J Nutr Biochem 2010
(Brain Neoplasms...) :
Suppression of
iNOS expression by fucoidan is
mediated by regulation of p38 MAPK,
JAK/STAT , AP-1 and IRF-1, and depends on up-regulation of scavenger receptor B1 expression in TNF-alpha- and IFN-gamma stimulated C6 glioma cells