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CFLAR — WNT2
Text-mined interactions from Literome
Naito et al., Mol Cell Biol 2004
:
Conversely, depletion of endogenous
cFLIP results in reduced
Wnt signaling ... These results indicate that
cFLIP-L , in cooperation with FADD,
enhances canonical
Wnt signaling by inhibiting proteasomal degradation of beta-catenin, thus suggesting an additional mechanism involved with tumorgenesis, in addition to inhibiting Fas signaling
Nakagiri et al., Mol Cell Biol 2005
:
Consequently, coexpression of E8 and
c-FLIP ( L ) synergistically
increased Wnt signaling in 293T cells
Ishioka et al., Genes Cells 2007
:
We previously reported that a long form of
cFLIP ( cFLIP-L ) inhibits ubiquitylation of beta-catenin and
enhances Wnt signaling
Katayama et al., J Cell Sci 2010
:
We previously reported that a long form of
cFLIP ( cFLIP-L )
enhances Wnt signaling via inhibition of beta-catenin ubiquitylation ... These results suggest a
role for nuclear
cFLIP-L in the modulation of
Wnt signaling