Gene interactions and pathways from curated databases and text-mining

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CD27 — NFKB1

Text-mined interactions from Literome

Nakano et al., Proc Natl Acad Sci U S A 1999 : Activation of either NF-kappaB or c-Jun NH ( 2 ) -terminal kinase/stress activated protein kinase by tumor necrosis factor, CD27 , and CD40 was not abrogated in traf5 ( -/- ) mice
Akiba et al., J Biol Chem 1998 : CD27 , a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB inducing kinase ... Here we demonstrate that overexpression of CD27 activates NF-kappaB and stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) ... Co-transfection of a dominant negative TRAF2 or TRAF5 blocked NF-kappaB and SAPK/JNK activation induced by CD27
Yamamoto et al., J Immunol 1998 : In the present study we demonstrate that overexpression of CD27 in 293 cells induces a low level of NF-kappaB activation, and the ligation of the receptor by its corresponding ligand ( CD70 ) augments this signal dramatically