Gene interactions and pathways from curated databases and text-mining

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FAS — YY1

Text-mined interactions from Literome

Vega et al., J Immunol 2005 (Lymphoma, Non-Hodgkin) : Inhibition of YY1 activity by either rituximab or the NO donor DETANONOate or after transfection with YY1 small interfering RNA resulted in up-regulation of Fas expression and sensitization to CH-11 induced apoptosis
Vega et al., Oncogene 2005 (Burkitt Lymphoma...) : Inhibition of YY1 resulted in the upregulation of Fas expression and sensitization of the tumor cells to CH-11 induced apoptosis ... The involvement of NF-kappaB and YY1 in the regulation of Fas expression was corroborated by the use of Ramos cells with a dominant-active inhibitor of NF-kappaB ( Ramos IkappaB-estrogen receptor ( ER ) mutant ) and by silencing YY1 with YY1 siRNA, respectively
Hongo et al., Biochem Biophys Res Commun 2005 (Prostatic Neoplasms) : Previous findings demonstrated that the transcription repressor Yin Yang 1 (YY1) , which is inhibited by NO, negatively regulates Fas transcription [ H.J. Garban, B. Bonavida, Nitric oxide inhibits the transcription repressor Yin-Yang 1 binding activity at the silencer region of the Fas promoter : a pivotal role for nitric oxide in the upregulation of Fas gene expression in human tumor cells, J. Immunol. 167 ( 2001 ) 75-81 ] ... The direct role of YY1 in the negative regulation of Fas expression was demonstrated by transfection of cells with siRNA YY1
Huerta-Yepez et al., Clin Immunol 2006 (Adenocarcinoma...) : We have reported that Fas expression and sensitivity to FasL is negatively regulated by the transcription repressor factor Yin Yang 1 (YY1)