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EPHB2 — SP1

Text-mined interactions from Literome

Chupreta et al., Am J Physiol Cell Physiol 2000 : Erk is capable of phosphorylating other mitogen-inducible transcription factors, e.g., Elk and Sap, suggesting that Erk may also mediate EGF dependent phosphorylation of Sp1
Xing et al., Biochem Biophys Res Commun 2002 : The role of Sp1 in BMP2-up regulated Erk2 gene expression
Bonello et al., J Biol Chem 2004 : Fibroblast growth factor-2 represses platelet derived growth factor receptor-alpha ( PDGFR-alpha ) transcription via ERK1/2 dependent Sp1 phosphorylation and an atypical cis acting element in the proximal PDGFR-alpha promoter ... These findings, taken together, demonstrate that FGF-2 stimulates ERK1/2 dependent Sp1 phosphorylation, thereby repressing PDGFR-alpha transcription via the -61/-52 element in the PDGFR-alpha promoter
Strowski et al., FASEB J 2004 (Helicobacter Infections...) : Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via MEK/ERK dependent activation of Sp1 and Sp3
Han et al., Int J Cancer 2005 (Carcinoma, Non-Small-Cell Lung...) : COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk : involvement of Sp1 and AP-1 sites
Spengler et al., Cell cycle (Georgetown, Tex.) 2008 : PKC, ERK , and ERBB2 kinase inhibitors suppress PMA induction of Sp1 and the specific isozyme PKCalpha enhances Sp1 cleavage
Liao et al., Mol Endocrinol 2008 : In conclusion, these studies have revealed a novel regulatory signaling mechanism of transcriptional control in which the LHR is derepressed through PKCalpha/ERK mediated Sp1 phosphorylation, causing the release of HDAC1/mSin3A complex from the promoter
Komatsu et al., Oncogene 2008 : We propose that Nox1 mediates oncogenic Ras induced upregulation of VEGF and angiogenesis by activating Sp1 through Ras-ERK dependent phosphorylation of Sp1
Kambe et al., Cancer prevention research (Philadelphia, Pa.) 2009 (Brain Neoplasms...) : Sp-1 phosphorylation was dependent on sulindac sulfide induced Erk activation
Boucher et al., Viral Immunol 2010 (HIV Infections...) : In primary monocytes, ERK and p38 inhibition increased binding of AP-1 and Sp1 , respectively, to the IL-12p40 promoter, while JNK inhibition increased NF-kappaB, AP-1, and Sp1 binding ... In THP-1 cells, p38, ERK , and JNK inhibition increased NF-kappaB and Sp1 binding to the IL-12p40 promoter, while inhibiting AP-1 binding
Wu et al., J Biol Chem 2010 (Reperfusion Injury) : ERK mediated phosphorylation of Sp1 was responsible for a decreased transcriptional activity of Sp1 in the kidney upon ischemia/reperfusion
Wang et al., J Cell Biochem 2010 : An ERK inhibitor suppressed Sp1 phosphorylation and bFGF reduced TSP50 expression at the mRNA level
Moon et al., Cell Mol Life Sci 2011 : Our results showed that the transcriptional activation of p21 by SP600125 is mediated through the proximal regions of multiple Sp1 sites in the p21 promoter following ERK dependent phosphorylation of Sp1
Feng et al., Cell Signal 2012 (MAP Kinase Signaling System) : Activated ERK by LPLI translocates from cytoplasm to nuclear and leads to increasing interaction with Sp1 , triggering a progressive phosphorylation of Sp1 on Thr453 and Thr739, resulting in the upregulation of VEGF expression
Kim et al., Aging Cell 2012 : In addition, epidermal growth factor stimulation induced p-ERK1/2 nuclear translocation and Elk-1 phosphorylation were severely impaired by Sp1 depletion in young HDFs ; Sp1 overexpression restored the nuclear translocation of p-ERK1/2 in senescent HDFs
García-Ruiz et al., Endocrinology 2012 (Fibrosis) : In conclusion, in HSCs, leptin up-regulates Col1a(I) gene expression after activating NADPH oxidase, inducing oxidative stress, aldehyde-protein adduct formation, and ERK1/2 phosphorylation, which in turn activates Sp1/Sp3 and provokes the binding of these two factors to regulatory elements located between -161 and -110 bp of the Col1a(I) promoter
Wu et al., J Lipid Res 2013 : In the early stage of sulfatide stimulation, phosphorylation of Erk as well as c-Src was noted, and inhibition of Erk activation with either U0126 or PD98059 significantly suppressed Sp1 phosphorylation and integrin aV expression