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CBL — IFNG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shamim et al., J Immunol 2007
(Disease Models, Animal...) :
Cbl-b regulates antigen induced TCR down-regulation and
IFN-gamma production by effector CD8 T cells without affecting functional avidity
D'Onofrio et al., Cancer Immunol Immunother 1990
(HTLV-I Infections) :
This resulted in : ( a ) a reduced number of virus positive cells until 4 weeks of culture ; ( b ) delay in the clonal expansion of infected cells ( IFN alpha and gamma); (c ) increased natural killer cell activity of
CBL , 1 week post-infection ( p.i. ),
mediated by
IFN gamma ; ( d ) increase of allospecific recognition of infecting and priming HTLV-I donor MT-2 cells by CBL in a cytotoxic-T-lymphocyte-like response, mediated by IFN and particularly by IFN gamma ; ( e ) phenotype distribution of CBL subpopulations, tested 4 days p.i., more similar to that of non infected CBL cultures