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HSF2 — IL2
Text-mined interactions from Literome
Haghighi et al., Immunopharmacology 1992
:
Hybridoma suppressor factor ( s ) (
HSF ), secreted by a human thymus hybridoma ( 8E-24 ) established in this laboratory,
suppresses Ig as well as
IL-2 synthesis by peripheral blood mononuclear cells ( PBMC )
Tomita et al., Immunobiology 1990
:
Additionally,
HSF did not
inhibit the expression of either
IL-2R ( p55 ) or TFR by activated T cells in spite of causing the suppression of IL-2 production
Murakami et al., Hybridoma 1988
:
Human
hybridoma suppressor factor ( HSF ) inhibits
IL2 production in addition to suppressing immunoglobulin production ... In this system
HSF significantly suppressed PHA
induced interleukin 2 ( IL2 ) production of peripheral blood mononuclear cells ( PBMC ) in a dose dependent fashion without inhibiting the proliferative response of CTLL-20 target cells to IL2 ... To investigate the role of
HSF induced
IL2 suppression in the pokeweed mitogen ( PWM ) antibody synthesis assay, the time course of IgG, IgM, IL1, and IL2 production of PWM stimulated PBMC cultures was examined
Tomita et al., Immunopharmacology 1988
:
Here we analysed, further, the mechanism of
HSF mediated suppression of Ig and
IL-2 production ... We demonstrated that
HSF inhibited PWM induced
IL-2 production by CD4+ cells but not by CD8+ cells and its suppressive activity on Ig production was totally abrogated by preabsorption with CD4+ cells, but not by CD8+ cells